TY - JOUR
T1 - Listeriosis in bone marrow transplant recipients
T2 - Incidence, clinical features, and treatment
AU - Chang, J.
AU - Powles, R.
AU - Mehta, J.
AU - Paton, N.
AU - Treleaven, J.
AU - Jameson, B.
N1 - Funding Information:
Received 2 November 1994; revised 3 April 1995. Financial support: This work was supported by the Bud Flanagan Leukaemia Fund, the Cancer Research Fund, and the Cancer Research Campaign. Reprints or correspondence: Dr. J. Chang, Department of Medicine, Royal Marsden Hospital, Sutton, Surrey SM2 5PT United Kingdom.
PY - 1995/11
Y1 - 1995/11
N2 - Cultures of blood and/or cerebrospinal fluid from four of 1,013 bone marrow transplant recipients treated at our center between January 1972 and April 1994 were positive for Listeria monocytogenes. The overall occurrence of listeriosis was 0.39 case per 100 transplantations. Allograft recipients had received prior treatment with parenteral methylprednisolone, thus supporting an association between listeriosis and corticosteroids. Treatment with parenteral ampicillin (200 mg/[kg · d]) and gentamicin is recommended for a minimum of 3 weeks before oral therapy. Two patients with penicillin allergies in this study failed to respond to chloramphenicol-based therapeutic regimens. Recurrent meningitis occurred in two patients, and the therapeutic use of intrathecal gentamicin/vancomycin did not confer a survival advantage (i.e., the patients did not survive).
AB - Cultures of blood and/or cerebrospinal fluid from four of 1,013 bone marrow transplant recipients treated at our center between January 1972 and April 1994 were positive for Listeria monocytogenes. The overall occurrence of listeriosis was 0.39 case per 100 transplantations. Allograft recipients had received prior treatment with parenteral methylprednisolone, thus supporting an association between listeriosis and corticosteroids. Treatment with parenteral ampicillin (200 mg/[kg · d]) and gentamicin is recommended for a minimum of 3 weeks before oral therapy. Two patients with penicillin allergies in this study failed to respond to chloramphenicol-based therapeutic regimens. Recurrent meningitis occurred in two patients, and the therapeutic use of intrathecal gentamicin/vancomycin did not confer a survival advantage (i.e., the patients did not survive).
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U2 - 10.1093/clinids/21.5.1289
DO - 10.1093/clinids/21.5.1289
M3 - Comment/debate
C2 - 8589157
AN - SCOPUS:0028842914
SN - 1058-4838
VL - 21
SP - 1289
EP - 1290
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 5
ER -