Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions

Janos Szebeni, Seyed Moein Moghimi

Research output: Contribution to journalComment/debate

64 Scopus citations

Abstract

This commentary focuses on therapeutic advantages as well as adverse reactions that entail liposome triggering of the innate immune system, notably the complement cascade and macrophage clearance mechanisms. Our discussion is centered on macrophage drug delivery, evasion of macrophage surveillance, immunogenicity, and hypersensitivity.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalJournal of Liposome Research
Volume19
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Complement inhibitor
  • Complement system
  • Drug delivery
  • Hypersensitivity
  • Immunogenicity
  • Liposome
  • Macrophage

ASJC Scopus subject areas

  • Pharmaceutical Science

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