Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions

Janos Szebeni; Seyed Moein Moghimi

doi:10.1080/08982100902792855

Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions

Janos Szebeni, Seyed Moein Moghimi

Research Institute

Research output: Contribution to journal › Comment/debate › peer-review

104 Scopus citations

Abstract

This commentary focuses on therapeutic advantages as well as adverse reactions that entail liposome triggering of the innate immune system, notably the complement cascade and macrophage clearance mechanisms. Our discussion is centered on macrophage drug delivery, evasion of macrophage surveillance, immunogenicity, and hypersensitivity.

Original language	English (US)
Pages (from-to)	85-90
Number of pages	6
Journal	Journal of Liposome Research
Volume	19
Issue number	2
DOIs	https://doi.org/10.1080/08982100902792855
State	Published - 2009

Keywords

Complement inhibitor
Complement system
Drug delivery
Hypersensitivity
Immunogenicity
Liposome
Macrophage

ASJC Scopus subject areas

Pharmaceutical Science

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10.1080/08982100902792855

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title = "Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions",

abstract = "This commentary focuses on therapeutic advantages as well as adverse reactions that entail liposome triggering of the innate immune system, notably the complement cascade and macrophage clearance mechanisms. Our discussion is centered on macrophage drug delivery, evasion of macrophage surveillance, immunogenicity, and hypersensitivity.",

keywords = "Complement inhibitor, Complement system, Drug delivery, Hypersensitivity, Immunogenicity, Liposome, Macrophage",

author = "Janos Szebeni and Moghimi, {Seyed Moein}",

note = "Funding Information: Financial support by the Danish Agency for Science, Technology and Innovation (Det Strategiske Forskningsr{\aa}d; reference 2106-08-0081) and the National Office for Research and Technology (NKTH), Budapest (NAP-NANO and CAPRA777) are gratefully acknowledged.",

year = "2009",

doi = "10.1080/08982100902792855",

language = "English (US)",

volume = "19",

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T1 - Liposome triggering of innate immune responses

T2 - A perspective on benefits and adverse reactions

AU - Szebeni, Janos

AU - Moghimi, Seyed Moein

N1 - Funding Information: Financial support by the Danish Agency for Science, Technology and Innovation (Det Strategiske Forskningsråd; reference 2106-08-0081) and the National Office for Research and Technology (NKTH), Budapest (NAP-NANO and CAPRA777) are gratefully acknowledged.

PY - 2009

Y1 - 2009

N2 - This commentary focuses on therapeutic advantages as well as adverse reactions that entail liposome triggering of the innate immune system, notably the complement cascade and macrophage clearance mechanisms. Our discussion is centered on macrophage drug delivery, evasion of macrophage surveillance, immunogenicity, and hypersensitivity.

AB - This commentary focuses on therapeutic advantages as well as adverse reactions that entail liposome triggering of the innate immune system, notably the complement cascade and macrophage clearance mechanisms. Our discussion is centered on macrophage drug delivery, evasion of macrophage surveillance, immunogenicity, and hypersensitivity.

KW - Complement inhibitor

KW - Complement system

KW - Drug delivery

KW - Hypersensitivity

KW - Immunogenicity

KW - Liposome

KW - Macrophage

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DO - 10.1080/08982100902792855

M3 - Comment/debate

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SN - 0898-2104

VL - 19

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EP - 90

JO - Journal of Liposome Research

JF - Journal of Liposome Research

IS - 2

ER -

Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions

Abstract

Keywords

ASJC Scopus subject areas

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