Lipoprotein-based drug delivery

Sara Busatto; Sierra A. Walker; Whisper Grayson; Anthony Pham; Ming Tian; Nicole Nesto; Jacqueline Barklund; Joy Wolfram

doi:10.1016/j.addr.2020.08.003

Lipoprotein-based drug delivery

Sara Busatto, Sierra A. Walker, Whisper Grayson, Anthony Pham, Ming Tian, Nicole Nesto, Jacqueline Barklund, Joy Wolfram

Houston Methodist

Research output: Contribution to journal › Review article › peer-review

99 Scopus citations

Abstract

Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.

Original language	English (US)
Pages (from-to)	377-390
Number of pages	14
Journal	Advanced Drug Delivery Reviews
Volume	159
Early online date	Aug 11 2020
DOIs	https://doi.org/10.1016/j.addr.2020.08.003
State	Published - 2020

Keywords

Biocompatible nanoparticles
Chemotherapy
Chylomicrons
Drug delivery
High-density lipoproteins
Low-density lipoproteins
Lymphatic transport
Purification
Synthetic lipoproteins
Very low-density lipoproteins

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/j.addr.2020.08.003

Cite this

@article{bbab9c9a847d48ee96bbede23cb33560,

title = "Lipoprotein-based drug delivery",

abstract = "Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.",

keywords = "Biocompatible nanoparticles, Chemotherapy, Chylomicrons, Drug delivery, High-density lipoproteins, Low-density lipoproteins, Lymphatic transport, Purification, Synthetic lipoproteins, Very low-density lipoproteins",

author = "Sara Busatto and Walker, \{Sierra A.\} and Whisper Grayson and Anthony Pham and Ming Tian and Nicole Nesto and Jacqueline Barklund and Joy Wolfram",

year = "2020",

doi = "10.1016/j.addr.2020.08.003",

language = "English (US)",

volume = "159",

pages = "377--390",

journal = "Advanced Drug Delivery Reviews",

issn = "0169-409X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Lipoprotein-based drug delivery

AU - Busatto, Sara

AU - Walker, Sierra A.

AU - Grayson, Whisper

AU - Pham, Anthony

AU - Tian, Ming

AU - Nesto, Nicole

AU - Barklund, Jacqueline

AU - Wolfram, Joy

PY - 2020

Y1 - 2020

N2 - Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.

AB - Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.

KW - Biocompatible nanoparticles

KW - Chemotherapy

KW - Chylomicrons

KW - Drug delivery

KW - High-density lipoproteins

KW - Low-density lipoproteins

KW - Lymphatic transport

KW - Purification

KW - Synthetic lipoproteins

KW - Very low-density lipoproteins

UR - https://www.scopus.com/pages/publications/85089725481

UR - https://www.scopus.com/inward/citedby.url?scp=85089725481&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2020.08.003

DO - 10.1016/j.addr.2020.08.003

M3 - Review article

C2 - 32791075

AN - SCOPUS:85089725481

SN - 0169-409X

VL - 159

SP - 377

EP - 390

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

Lipoprotein-based drug delivery

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this