Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review

Adnan Younus; Choudhry Humayun; Rameez Ahmad; Oluseye Ogunmoroti; Yugandhar Kandimalla; Muhammad Aziz; Rehan Malik; Aisha Rasool Saand; Cyndi Valdes; Rohan Badlani; Muhammad Amir Younus; Shozab S. Ali; Ye Chen; Khurram Nasir

doi:10.1016/j.jacl.2017.02.005

Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review

Adnan Younus, Choudhry Humayun, Rameez Ahmad, Oluseye Ogunmoroti, Yugandhar Kandimalla, Muhammad Aziz, Rehan Malik, Aisha Rasool Saand, Cyndi Valdes, Rohan Badlani, Muhammad Amir Younus, Shozab S. Ali, Ye Chen, Khurram Nasir

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Background Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that exhibits proinflammatory properties and has been associated with subclinical cardiovascular disease. Objective The relationship between Lp-PLA2 and subclinical CVD remains unclear. The goal of this systematic review was to clarify this relationship. Methods An extensive literature search of the MEDLINE database using Ovid and PubMed was performed. From an initial search of 444 articles, 13 met the inclusion and exclusion criteria and were included in the review. Results Of the 13 studies included in the review, 6 examined the relationship between Lp-PLA2 and coronary artery calcification, of which 3 showed a significant correlation. Two studies examined the relationship between Lp-PLA2 and endothelial dysfunction, and 1 reported a significant relationship. Five studies investigated the association of Lp-PLA2 with carotid intima-media thickness (CIMT), and 3 reported a significant relationship. Conclusions This review shows a variable association between Lp-PLA2 and subclinical disease. This finding has broad implications for the future of public health and clinical practice. Future research is needed to clarify what role Lp-PLA2 has in guiding treatment and if it is involved in plaque instability, which would make it a useful tool for risk prognostication.

Original language	English (US)
Pages (from-to)	328-337
Number of pages	10
Journal	Journal of Clinical Lipidology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.jacl.2017.02.005
State	Published - Mar 2017

Keywords

LP-PLA2
Lipoprotein
Subclinical

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics
Cardiology and Cardiovascular Medicine

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10.1016/j.jacl.2017.02.005

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Younus, A., Humayun, C., Ahmad, R., Ogunmoroti, O., Kandimalla, Y., Aziz, M., Malik, R., Saand, A. R., Valdes, C., Badlani, R., Younus, M. A., Ali, S. S., Chen, Y., & Nasir, K. (2017). Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review. Journal of Clinical Lipidology, 11(2), 328-337. https://doi.org/10.1016/j.jacl.2017.02.005

Younus, A, Humayun, C, Ahmad, R, Ogunmoroti, O, Kandimalla, Y, Aziz, M, Malik, R, Saand, AR, Valdes, C, Badlani, R, Younus, MA, Ali, SS, Chen, Y & Nasir, K 2017, 'Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review', Journal of Clinical Lipidology, vol. 11, no. 2, pp. 328-337. https://doi.org/10.1016/j.jacl.2017.02.005

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title = "Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review",

abstract = "Background Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that exhibits proinflammatory properties and has been associated with subclinical cardiovascular disease. Objective The relationship between Lp-PLA2 and subclinical CVD remains unclear. The goal of this systematic review was to clarify this relationship. Methods An extensive literature search of the MEDLINE database using Ovid and PubMed was performed. From an initial search of 444 articles, 13 met the inclusion and exclusion criteria and were included in the review. Results Of the 13 studies included in the review, 6 examined the relationship between Lp-PLA2 and coronary artery calcification, of which 3 showed a significant correlation. Two studies examined the relationship between Lp-PLA2 and endothelial dysfunction, and 1 reported a significant relationship. Five studies investigated the association of Lp-PLA2 with carotid intima-media thickness (CIMT), and 3 reported a significant relationship. Conclusions This review shows a variable association between Lp-PLA2 and subclinical disease. This finding has broad implications for the future of public health and clinical practice. Future research is needed to clarify what role Lp-PLA2 has in guiding treatment and if it is involved in plaque instability, which would make it a useful tool for risk prognostication.",

keywords = "LP-PLA2, Lipoprotein, Subclinical",

author = "Adnan Younus and Choudhry Humayun and Rameez Ahmad and Oluseye Ogunmoroti and Yugandhar Kandimalla and Muhammad Aziz and Rehan Malik and Saand, {Aisha Rasool} and Cyndi Valdes and Rohan Badlani and Younus, {Muhammad Amir} and Ali, {Shozab S.} and Ye Chen and Khurram Nasir",

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doi = "10.1016/j.jacl.2017.02.005",

language = "English (US)",

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T1 - Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease

T2 - A systematic review

AU - Younus, Adnan

AU - Humayun, Choudhry

AU - Ahmad, Rameez

AU - Ogunmoroti, Oluseye

AU - Kandimalla, Yugandhar

AU - Aziz, Muhammad

AU - Malik, Rehan

AU - Saand, Aisha Rasool

AU - Valdes, Cyndi

AU - Badlani, Rohan

AU - Younus, Muhammad Amir

AU - Ali, Shozab S.

AU - Chen, Ye

AU - Nasir, Khurram

PY - 2017/3

Y1 - 2017/3

N2 - Background Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that exhibits proinflammatory properties and has been associated with subclinical cardiovascular disease. Objective The relationship between Lp-PLA2 and subclinical CVD remains unclear. The goal of this systematic review was to clarify this relationship. Methods An extensive literature search of the MEDLINE database using Ovid and PubMed was performed. From an initial search of 444 articles, 13 met the inclusion and exclusion criteria and were included in the review. Results Of the 13 studies included in the review, 6 examined the relationship between Lp-PLA2 and coronary artery calcification, of which 3 showed a significant correlation. Two studies examined the relationship between Lp-PLA2 and endothelial dysfunction, and 1 reported a significant relationship. Five studies investigated the association of Lp-PLA2 with carotid intima-media thickness (CIMT), and 3 reported a significant relationship. Conclusions This review shows a variable association between Lp-PLA2 and subclinical disease. This finding has broad implications for the future of public health and clinical practice. Future research is needed to clarify what role Lp-PLA2 has in guiding treatment and if it is involved in plaque instability, which would make it a useful tool for risk prognostication.

AB - Background Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that exhibits proinflammatory properties and has been associated with subclinical cardiovascular disease. Objective The relationship between Lp-PLA2 and subclinical CVD remains unclear. The goal of this systematic review was to clarify this relationship. Methods An extensive literature search of the MEDLINE database using Ovid and PubMed was performed. From an initial search of 444 articles, 13 met the inclusion and exclusion criteria and were included in the review. Results Of the 13 studies included in the review, 6 examined the relationship between Lp-PLA2 and coronary artery calcification, of which 3 showed a significant correlation. Two studies examined the relationship between Lp-PLA2 and endothelial dysfunction, and 1 reported a significant relationship. Five studies investigated the association of Lp-PLA2 with carotid intima-media thickness (CIMT), and 3 reported a significant relationship. Conclusions This review shows a variable association between Lp-PLA2 and subclinical disease. This finding has broad implications for the future of public health and clinical practice. Future research is needed to clarify what role Lp-PLA2 has in guiding treatment and if it is involved in plaque instability, which would make it a useful tool for risk prognostication.

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Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review

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Keywords

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