@article{7056030f067b49a6ac0354bd12c2da2f,
title = "Lipoprotein-apoprotein exchange in aqueous systems: Relevance to the occurrence of APOA-I and APOC proteins in a common particle",
abstract = "Human plasma high density lipoproteins (HDL) were labeled in vitro with [125I]apoA-I. Chromatography of the [125I]HDL on Sephacryl S-200 revealed that a certain fraction of [125I]apoA-I readily dissociates from the intact particle over a wide range of HDL concentrations. The relatively constant value of the dissociated apoA-I concentration observed at various HDL concentrations suggests that a {"}critical monomer concentration{"} of apoA-I is in equilibrium with the parent lipoprotein. Addition of [131I]apoC proteins to HDL induces additional dissociation of oligomeric apoA-I with the concomitant incorporation of apoC into a new particle of about 460,000 daltons.",
author = "Pownall, {Henry J.} and Quein Pao and Michael Rohde and Antonio Gotto",
note = "Funding Information: This work was supported by grants from the American Heart Association (HJP) and the National Institutes of Health (HL-19459). Portions of this research were developed by the Atheroscierosis, Lipids and Lipoproteins section of the National Heart and Blood Vessel Research and Demonstration Center, Baylor College of Medicine, a grant-supported research project of National Heart, Lung, and Blood Institute, National Institutes of Health, Grant No. HL 17269. We acknowledge the assistance of Ms. Debbie Mason and Mrs. Sharon Bonnot in preparing the manuscript and Ms. Kaye Shewmaker in preparing the figures. HJP is an Established Investigator of the American Heart Association.",
year = "1978",
month = nov,
day = "14",
doi = "10.1016/S0006-291X(78)80057-6",
language = "English (US)",
volume = "85",
pages = "408--414",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier B.V.",
number = "1",
}