Lipid–polymer hybrid nanoparticle-mediated therapeutics delivery: advances and challenges

Rajendran J.C. Bose, Rramaswamy Ravikumar, Vengadeshprabu Karuppagounder, Devasier Bennet, Sabarinathan Rangasamy, Rajarajan A. Thandavarayan

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


With rapid advances in nanomedicine, lipid–polymer hybrid nanoparticles (LPHNPs) have emerged as promising nanocarriers for several biomedical applications, including therapeutics delivery and biomedical imaging. Significant research has been dedicated to biomimetic or targeting functionalization, as well as controlled and image-guided drug-release capabilities. Despite this research, the clinical translation of LPHNP-mediated therapeutics delivery has progressed incrementally. In this review, we discuss the recent advances in and challenges to the development and application of LPHNPs, present examples to demonstrate the advantages of LPHNPs in therapeutics delivery and imaging applications, and discuss the translational obstacles to LPHNP technology.

Original languageEnglish (US)
Pages (from-to)1258-1265
Number of pages8
JournalDrug Discovery Today
Issue number8
StatePublished - Aug 2017

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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