Lipid-modifying activity of curcuminoids: A systematic review and meta-analysis of randomized controlled trials

Luis E. Simental-Mendía, Matteo Pirro, Antonio Gotto, Maciej Banach, Stephen L. Atkin, Muhammed Majeed, Amirhossein Sahebkar

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Objective: The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels. Methods: Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3rd, 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations. Results: A meta-analysis of 20 RCTs with 1427 participants suggested a significant decrease in plasma concentrations of triglycerides (WMD: −21.36 mg/dL, 95% CI: −32.18, −10.53, p < 0.001), and an elevation in plasma HDL-C levels (WMD: 1.42 mg/dL, 95% CI: 0.03, 2.81, p = 0.046), while plasma levels of LDL-C (WMD: −5.82 mg/dL, 95% CI: −15.80, 4.16, p = 0.253) and total cholesterol (WMD: −9.57 mg/dL, 95% CI: −20.89, 1.75, p = 0.098) were not altered. The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation. Conclusion: This meta-analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels.

Original languageEnglish (US)
Pages (from-to)1178-1187
Number of pages10
JournalCritical Reviews in Food Science and Nutrition
Volume59
Issue number7
DOIs
StatePublished - Apr 12 2019

Keywords

  • Cardiovascular disease
  • Cholesterol
  • Curcumin
  • Dyslipidemia
  • Triglycerides
  • Turmeric

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering

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