Linkage disequilibrium mapping of novel lung tumor susceptibility quantitative trait loci in mice

Daolong Wang, William J. Lemon, Ming You

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Linkage disequilibrium (LD) has been used to map chromosomal regions regulating quantitative traits, also called quantitative trait loci (QTLs). With the increasing number of available mouse polymorphic genetic markers, LD can be estimated for the purpose of fine-mapping a given QTL or in the identification of novel QTLs. A whole-genome LD analysis was conducted for mapping mouse lung tumor susceptibility QTLs in 25 strains of mice with known susceptibility to lung cancer using 5638 genetic markers. A total of 63 markers were found to be significantly associated with lung tumor susceptibility, many of which were novel QTLs. This study demonstrates the feasibility of using LD to map QTLs on a whole genome level. Further characterization of the newly identified lung tumor susceptibility QTLs may lead to the identification of genes whose human homologue may predispose some individuals to lung cancer.

Original languageEnglish (US)
Pages (from-to)6858-6865
Number of pages8
JournalOncogene
Volume21
Issue number44
DOIs
StatePublished - Oct 3 2002

Keywords

  • Gene mapping
  • Linkage disequilibrium
  • Lung tumor
  • Mouse
  • Susceptibility

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint

Dive into the research topics of 'Linkage disequilibrium mapping of novel lung tumor susceptibility quantitative trait loci in mice'. Together they form a unique fingerprint.

Cite this