LINGO1 rs9652490 variant in Parkinson disease patients

Yi Guo; Joseph Jankovic; Zhi Song; Huarong Yang; Wen Zheng; Weidong Le; Xiangqi Tang; Xiong Deng; Yan Yang; Sheng Deng; Ziqiang Luo; Hao Deng

doi:10.1016/j.neulet.2010.10.016

LINGO1 rs9652490 variant in Parkinson disease patients

Yi Guo, Joseph Jankovic, Zhi Song, Huarong Yang, Wen Zheng, Weidong Le, Xiangqi Tang, Xiong Deng, Yan Yang, Sheng Deng, Ziqiang Luo, Hao Deng

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

Essential tremor (ET) has been hypothesized to be a risk factor for the development of Parkinson disease (PD). Recently, rs9652490 variant in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was found to be associated with ET susceptibility. To evaluate whether the same variant is associated also with PD susceptibility, we investigated the association between the LINGO1 rs9652490 variant and PD phenotype in Caucasian and Chinese PD subjects. We found no significant differences in genotypic and allele distribution between patients and control subjects (χ²=1.931, p=0.381 for genotypic distribution; χ²=0.001, p=0.973 for allele distribution), suggesting this variant is not associated with PD.

Original language	English (US)
Pages (from-to)	174-176
Number of pages	3
Journal	Neuroscience Letters
Volume	487
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2010.10.016
State	Published - Jan 7 2011

Keywords

Parkinson disease
Rs9652490
Susceptibility
The leucine-rich repeat and Ig domain containing 1 gene

ASJC Scopus subject areas

Neuroscience(all)

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title = "LINGO1 rs9652490 variant in Parkinson disease patients",

abstract = "Essential tremor (ET) has been hypothesized to be a risk factor for the development of Parkinson disease (PD). Recently, rs9652490 variant in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was found to be associated with ET susceptibility. To evaluate whether the same variant is associated also with PD susceptibility, we investigated the association between the LINGO1 rs9652490 variant and PD phenotype in Caucasian and Chinese PD subjects. We found no significant differences in genotypic and allele distribution between patients and control subjects (χ2=1.931, p=0.381 for genotypic distribution; χ2=0.001, p=0.973 for allele distribution), suggesting this variant is not associated with PD.",

keywords = "Parkinson disease, Rs9652490, Susceptibility, The leucine-rich repeat and Ig domain containing 1 gene",

author = "Yi Guo and Joseph Jankovic and Zhi Song and Huarong Yang and Wen Zheng and Weidong Le and Xiangqi Tang and Xiong Deng and Yan Yang and Sheng Deng and Ziqiang Luo and Hao Deng",

year = "2011",

month = jan,

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doi = "10.1016/j.neulet.2010.10.016",

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T1 - LINGO1 rs9652490 variant in Parkinson disease patients

AU - Guo, Yi

AU - Jankovic, Joseph

AU - Song, Zhi

AU - Yang, Huarong

AU - Zheng, Wen

AU - Le, Weidong

AU - Tang, Xiangqi

AU - Deng, Xiong

AU - Yang, Yan

AU - Deng, Sheng

AU - Luo, Ziqiang

AU - Deng, Hao

PY - 2011/1/7

Y1 - 2011/1/7

N2 - Essential tremor (ET) has been hypothesized to be a risk factor for the development of Parkinson disease (PD). Recently, rs9652490 variant in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was found to be associated with ET susceptibility. To evaluate whether the same variant is associated also with PD susceptibility, we investigated the association between the LINGO1 rs9652490 variant and PD phenotype in Caucasian and Chinese PD subjects. We found no significant differences in genotypic and allele distribution between patients and control subjects (χ2=1.931, p=0.381 for genotypic distribution; χ2=0.001, p=0.973 for allele distribution), suggesting this variant is not associated with PD.

AB - Essential tremor (ET) has been hypothesized to be a risk factor for the development of Parkinson disease (PD). Recently, rs9652490 variant in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was found to be associated with ET susceptibility. To evaluate whether the same variant is associated also with PD susceptibility, we investigated the association between the LINGO1 rs9652490 variant and PD phenotype in Caucasian and Chinese PD subjects. We found no significant differences in genotypic and allele distribution between patients and control subjects (χ2=1.931, p=0.381 for genotypic distribution; χ2=0.001, p=0.973 for allele distribution), suggesting this variant is not associated with PD.

KW - Parkinson disease

KW - Rs9652490

KW - Susceptibility

KW - The leucine-rich repeat and Ig domain containing 1 gene

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