@article{af6e5fe076614496b3242fbe4fba6f34,
title = "LINGO1 rs9652490 variant in Parkinson disease patients",
abstract = "Essential tremor (ET) has been hypothesized to be a risk factor for the development of Parkinson disease (PD). Recently, rs9652490 variant in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was found to be associated with ET susceptibility. To evaluate whether the same variant is associated also with PD susceptibility, we investigated the association between the LINGO1 rs9652490 variant and PD phenotype in Caucasian and Chinese PD subjects. We found no significant differences in genotypic and allele distribution between patients and control subjects (χ2=1.931, p=0.381 for genotypic distribution; χ2=0.001, p=0.973 for allele distribution), suggesting this variant is not associated with PD.",
keywords = "Parkinson disease, Rs9652490, Susceptibility, The leucine-rich repeat and Ig domain containing 1 gene",
author = "Yi Guo and Joseph Jankovic and Zhi Song and Huarong Yang and Wen Zheng and Weidong Le and Xiangqi Tang and Xiong Deng and Yan Yang and Sheng Deng and Ziqiang Luo and Hao Deng",
note = "Funding Information: This study was supported by the fund of Hunan Province for Distinguished Young Scholar ( 09JJ1005 ), Sheng Hua Scholars Program and Outstanding Youth Foundation of Central South University , China (H.D.), National Natural Science Foundation of China ( 30871351, 30971534 ), Students Innovative Pilot Scheme of Central South University , China ( YC10106 ), Program for New Century Excellent Talents in University of Ministry of Education of P.R. China (NCET-080563), the Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of P.R. China (H.D.), and Science Development Foundation of Central South University (10Sdf09). The authors thank the participating patients and the investigators at Department of Neurology, Baylor College of Medicine and Department of Neurology, the Third Xiangya Hospital, Central South University, for their cooperation and their efforts in collecting the genetic information and DNA specimens.",
year = "2011",
month = jan,
day = "7",
doi = "10.1016/j.neulet.2010.10.016",
language = "English (US)",
volume = "487",
pages = "174--176",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",
}