LINGO1 rs9652490 variant in Parkinson disease patients

Yi Guo, Joseph Jankovic, Zhi Song, Huarong Yang, Wen Zheng, Weidong Le, Xiangqi Tang, Xiong Deng, Yan Yang, Sheng Deng, Ziqiang Luo, Hao Deng

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Essential tremor (ET) has been hypothesized to be a risk factor for the development of Parkinson disease (PD). Recently, rs9652490 variant in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was found to be associated with ET susceptibility. To evaluate whether the same variant is associated also with PD susceptibility, we investigated the association between the LINGO1 rs9652490 variant and PD phenotype in Caucasian and Chinese PD subjects. We found no significant differences in genotypic and allele distribution between patients and control subjects (χ2=1.931, p=0.381 for genotypic distribution; χ2=0.001, p=0.973 for allele distribution), suggesting this variant is not associated with PD.

Original languageEnglish (US)
Pages (from-to)174-176
Number of pages3
JournalNeuroscience Letters
Volume487
Issue number2
DOIs
StatePublished - Jan 7 2011

Keywords

  • Parkinson disease
  • Rs9652490
  • Susceptibility
  • The leucine-rich repeat and Ig domain containing 1 gene

ASJC Scopus subject areas

  • Neuroscience(all)

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