Ligands for copper-catalyzed C-N bond forming reactions with 1 Mol% CuBr as catalyst

Kai Yang, Yatao Qiu, Zheng Li, Zhaoyang Wang, Sheng Jiang

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

Several new ligands were designed to promote copper-catalyzed Ullman C-N coupling reactions. In this group, 8-hydroxyquinolin-N-oxide was found to serve as a superior ligand for CuBr-catalyzed coupling reactions of aryl iodides, bromides, and chlorides with aliphatic amines and N-heterocycles under a low catalyst loading (1% [Cu] mol). Reactions with the inexpensive catalytic system display a high functional group tolerance as well as excellent chemoselectivity.

Original languageEnglish (US)
Pages (from-to)3151-3159
Number of pages9
JournalJournal of Organic Chemistry
Volume76
Issue number9
DOIs
StatePublished - May 6 2011

ASJC Scopus subject areas

  • Organic Chemistry

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