Ligand-dependent interaction of the dioxin receptor with target DNA

Scott Cuthill, Janet Hapgood, Marc Denis, Anna Wilhelmsson, Grant Mason, Nemoto Takayuki, Eva Widmark, Lorenz Poellinger, Jan Åke Gustafsson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Wild type and nuclear transfer deficient mouse hepatoma cell lines were used to study the specific DNA binding of a dioxin inducible factor. This factor interacts with XRE only after dioxin treatment and is absent in receptor mutant containing cells even after treatment. Thus, evidence is provided to substantiate the claim that the dioxin receptor is involved in the specific DNA interaction with dioxin response enhancer elements. It is also shown that the molybdate stabilised dioxin-receptor interacts with hsp90 suggesting that, in similarity to the glucocorticoid receptor, the dioxin receptor is kept in a non-transformed state in the absence of ligand.

Original languageEnglish (US)
Pages (from-to)375-377
Number of pages3
JournalJournal of Steroid Biochemistry
Volume34
Issue number1-6
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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