Levetiracetam compared to phenytoin for the prevention of postoperative seizures after craniotomy for intracranial tumours in patients without epilepsy

K. Kern, K. M. Schebesch, J. Schlaier, E. Hansen, Guenther C. Feigl, A. T. Brawanski, M. Lange

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Anticonvulsant drugs are frequently given after craniotomy. Phenytoin (PHT) is the most commonly used agent; levetiracetam (LEV) is a new anticonvulsant drug with fewer side effects. To compare the incidence of seizures in patients receiving either prophylactic PHT or LEV perioperatively, 971 patients undergoing a craniotomy were analysed retrospectively during a 2-year period. PHT was used routinely and LEV was administered when PHT was contraindicated. Seizures documented during the first 7 days after craniotomy were considered. A total of 235 patients were treated with an antiepileptic drug: 81 patients received LEV, and 154 patients, PHT. Two patients receiving LEV (2.5%) and seven receiving PHT (4.5%) had a seizure despite this treatment. No patient had a documented side effect or drug interaction. The data show that LEV may be an alternative option in patients with contraindications to PHT.

Original languageEnglish (US)
Pages (from-to)99-100
Number of pages2
JournalJournal of Clinical Neuroscience
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • Anticonvulsants
  • Craniotomy
  • Levetiracetam
  • Phenytoin
  • Seizure

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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