Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane

Giacomo Bruno, Thomas Geninatti, R. Lyle Hood, Daniel Fine, Giovanni Scorrano, Jeffrey Schmulen, Sharath Hosali, Mauro Ferrari, Alessandro Grattoni

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

General adoption of advanced treatment protocols such as chronotherapy will hinge on progress in drug delivery technologies that provide precise temporal control of therapeutic release. Such innovation is also crucial to future medicine approaches such as telemedicine. Here we present a nanofluidic membrane technology capable of achieving active and tunable control of molecular transport through nanofluidic channels. Control was achieved through application of an electric field between two platinum electrodes positioned on either surface of a 5.7 nm nanochannel membrane designed for zero-order drug delivery. Two electrode configurations were tested: laser-cut foils and electron beam deposited thin-films, configurations capable of operating at low voltage (≤1.5 V), and power (100 nW). Temporal, reproducible tuning and interruption of dendritic fullerene 1 (DF-1) transport was demonstrated over multi-day release experiments. Conductance tests showed limiting currents in the low applied potential range, implying ionic concentration polarization (ICP) at the interface between the membrane's micro- and nanochannels, even in concentrated solutions (≤1 M NaCl). The ability of this nanotechnology platform to facilitate controlled delivery of molecules and particles has broad applicability to next-generation therapeutics for numerous pathologies, including autoimmune diseases, circadian dysfunction, pain, and stress, among others.

Original languageEnglish (US)
Pages (from-to)5240-5248
Number of pages9
JournalNanoscale
Volume7
Issue number12
DOIs
StatePublished - Mar 28 2015

ASJC Scopus subject areas

  • Materials Science(all)

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