Leukocyte immunoglobulin-like receptors in human diseases: An overview of their distribution, function, and potential application for immunotherapies

Jilu Zhang, Sunny Mai, Hui-Ming Chen, Kyeongah Kang, Xian Chang Li, Shu Hsia Chen, Ping Ying Pan

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Myeloid-derived suppressor cells (MDSCs), a population of immature myeloid cells expanded and accumulated in tumor-bearing mice and in patients with cancer, have been shown to mediate immune suppression and to promote tumor progression, thereby, posing a major hurdle to the success of immune-activating cancer therapies. MDSCs, like their healthy counterparts, such as monocytes/macrophages and granulocytes, express an array of costimulatory and coinhibitory molecules as well as myeloid activators and inhibitory receptors, such as leukocyte immunoglobulin-like receptors (LILR) A and B. This review summarizes current findings on the LILR family members in various diseases, their potential roles in the pathogenesis, and possible strategies to revert or enhance the suppressive function of MDSCs for the benefit of patients by targeting LILRs.

Original languageEnglish (US)
Pages (from-to)351-360
Number of pages10
JournalJournal of Leukocyte Biology
Volume102
Issue number2
Early online dateMar 28 2017
DOIs
StatePublished - Aug 1 2017

Keywords

  • Autoimmunity
  • Cancer
  • Infection
  • MDSCs
  • Transplant tolerance

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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