TY - JOUR
T1 - Leukocyte immunoglobulin-like receptors in human diseases
T2 - An overview of their distribution, function, and potential application for immunotherapies
AU - Zhang, Jilu
AU - Mai, Sunny
AU - Chen, Hui-Ming
AU - Kang, Kyeongah
AU - Li, Xian Chang
AU - Chen, Shu Hsia
AU - Pan, Ping Ying
N1 - © Society for Leukocyte Biology.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Myeloid-derived suppressor cells (MDSCs), a population of immature myeloid cells expanded and accumulated in tumor-bearing mice and in patients with cancer, have been shown to mediate immune suppression and to promote tumor progression, thereby, posing a major hurdle to the success of immune-activating cancer therapies. MDSCs, like their healthy counterparts, such as monocytes/macrophages and granulocytes, express an array of costimulatory and coinhibitory molecules as well as myeloid activators and inhibitory receptors, such as leukocyte immunoglobulin-like receptors (LILR) A and B. This review summarizes current findings on the LILR family members in various diseases, their potential roles in the pathogenesis, and possible strategies to revert or enhance the suppressive function of MDSCs for the benefit of patients by targeting LILRs.
AB - Myeloid-derived suppressor cells (MDSCs), a population of immature myeloid cells expanded and accumulated in tumor-bearing mice and in patients with cancer, have been shown to mediate immune suppression and to promote tumor progression, thereby, posing a major hurdle to the success of immune-activating cancer therapies. MDSCs, like their healthy counterparts, such as monocytes/macrophages and granulocytes, express an array of costimulatory and coinhibitory molecules as well as myeloid activators and inhibitory receptors, such as leukocyte immunoglobulin-like receptors (LILR) A and B. This review summarizes current findings on the LILR family members in various diseases, their potential roles in the pathogenesis, and possible strategies to revert or enhance the suppressive function of MDSCs for the benefit of patients by targeting LILRs.
KW - Autoimmunity
KW - Cancer
KW - Infection
KW - MDSCs
KW - Transplant tolerance
UR - http://www.scopus.com/inward/record.url?scp=85026725702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026725702&partnerID=8YFLogxK
U2 - 10.1189/jlb.5MR1216-534R
DO - 10.1189/jlb.5MR1216-534R
M3 - Review article
C2 - 28351852
VL - 102
SP - 351
EP - 360
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
SN - 0741-5400
IS - 2
ER -