Letter: Differentiation of isomeric mercapturic acid pathway metabolites of benzo[a]pyrene

Y. Yang, J. Rafter, J. Å Gustafsson, J. Sjövall, W. J. Griffiths

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Isomeric forms of the mercapturic acid pathway metabolites of benzo[a]pyrene (BP) can be differentiated by positive-ion electrospray collision-induced dissociation (CID) mass spectrometry at the nanogram level. The metabolite (±)-r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), conjugated at position 10 (bay region) with cysteine, fragments to give characteristic ions at m/z 303 corresponding to a BP-triol cation, these ions are not observed in the CID spectra of BPDEs conjugated at position 7 (non-bay region).

Original languageEnglish (US)
Pages (from-to)396-399
Number of pages4
JournalEuropean Mass Spectrometry
Volume3
Issue number5
DOIs
StatePublished - 1997

Keywords

  • Benzo[a]pyrene
  • Diolepoxides
  • Electrospray
  • Mass spectrometry
  • Mercapturic acid
  • Metabolites
  • N-acetylcysteine
  • Tandem mass spectrometry

ASJC Scopus subject areas

  • Spectroscopy

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