Lessons learned and real-world insights from implementing neutralizing monoclonal antibody programs for treatment of COVID-19

Nalini Ambrose, Alpesh N. Amin, Brian Anderson, Adam Aten, Brian Canter, Daniel Chow, Matthew D’Ambrosio, Risa Danan, Ashley L. Drews, Fraser W. Gaspar, Rachele Hendricks-Sturrup, John O'Horo, Raymund R. Razonable, Seth Roberts, Colin Shepard, Farhaan Vahidy, Brandon Webb, Jennifer Yttri

Research output: Contribution to journalArticlepeer-review

Abstract

Coronavirus disease-2019 precipitated the rapid deployment of novel therapeutics, which led to operational and logistical challenges for healthcare organizations. Four health systems participated in a qualitative study to abstract lessons learned, challenges, and promising practices from implementing neutralizing monoclonal antibody (nMAb) treatment programs. Lessons are summarized under three themes that serve as critical building blocks for health systems to rapidly deploy novel therapeutics during a pandemic: (1) clinical workflows, (2) data infrastructure and platforms, and (3) governance and policy. Health systems must be sufficiently agile to quickly scale programs and resources in times of uncertainty. Real-time monitoring of programs, policies, and processes can help support better planning and improve program effectiveness. The lessons and promising practices shared in this study can be applied by health systems for distribution of novel therapeutics beyond nMAbs and toward future pandemics and public health emergencies.

Original languageEnglish (US)
Article numbere76
JournalData and Policy
Volume6
DOIs
StatePublished - Dec 19 2024

Keywords

  • coronavirus disease-19
  • monoclonal antibodies
  • pandemic preparedness

ASJC Scopus subject areas

  • Computer Science (miscellaneous)
  • Artificial Intelligence
  • Social Sciences (miscellaneous)
  • Public Administration

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