Lesions of anogenital mammary-like glands: Four cases including novel pathologic and immunohistochemical observations

Komal Arora, Ziad M. El-Zaatari, Mary R. Schwartz, Jae Y. Ro

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Anogenital mammary-like glands, formerly described as ectopic breast tissue, are currently considered to be normal histologic components of the anogenital region. Anogenital mammary-like glands can give rise to many lesions identical to counterparts in the native female breast. We describe four cases of such lesions, including fibroadenoma, gynecomastia-like hyperplasia, and ectopic mammary-type tissue with a spectrum of usual ductal hyperplasia, apocrine metaplasia, adenosis, and pseudolactational change. All four cases occurred in young women (ages 29–38) who presented with vulvar or perianal masses. Similar to previously reported cases, these lesions shared histologic and immunohistochemical characteristics identical to native female breast lesions. Novel findings in our cases included, (1) the first case of gynecomastia-like change to be reported in the perianal area of a female, (2) Immunohistochemical staining identifying a 3-layered epithelium characterized by a population of CK14 and CK5/6 positive and hormone receptor negative superficial luminal cells, and (3) diffuse, strong positivity for GATA3 in all cases. Our study adds to the literature on these rare lesions and highlights findings which may be useful in understanding the pathogenesis and improving the diagnosis of anogenital mammary-like gland lesions.

Original languageEnglish (US)
Article number151551
Pages (from-to)151551
JournalAnnals of Diagnostic Pathology
StatePublished - Aug 2020


  • Anogenital mammary like glands
  • Ectopic breast tissue
  • Fibroadenoma
  • GATA3
  • Gynecomastia-like change

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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