BACKGROUND Leptomeningeal carcinomatosis is a rare feature of metastasis that is characterized by thickening and increased contrast enhancement throughout the meninges of the central nervous system (CNS). Leptomeningeal disease (LMD) can occur as spread from primary CNS tumors or as a manifestation of metastasis to the CNS from primary tumor sites outside the CNS. Leptomeningeal disease is, however, rare in cervical cancer, in which metastasis occurs typically from local invasion. OBSERVATIONS The authors discuss the case of CNS metastasis with LMD from the rare neuroendocrine carcinoma of the cervix (NECC). Cervical cancer infrequently metastasizes to the CNS, but NECC is an aggressive variant with greater metastatic potential. Many of these patients will have previously received pelvic radiation, limiting their candidacy for craniospinal radiation for LMD treatment due to field overlap. This illustrative case documents the first known case of NECC CNS metastasis accompanied by LMD treated with intrathecal chemotherapy. LESSONS Reported is the first known case of NECC with CNS metastasis accompanied by LMD. The authors highlight the potentially critical role of intrathecal chemotherapy, in addition to radiotherapy, in treating leptomeningeal metastasis from cervical cancer.

Original languageEnglish (US)
Article numberCASE22457
JournalJournal of Neurosurgery: Case Lessons
Issue number5
StatePublished - Jan 2023


  • brain metastasis
  • cervical cancer
  • intrathecal chemotherapy
  • leptomeningeal disease
  • neuroendocrine carcinoma of the cervix

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


Dive into the research topics of 'Leptomeningeal metastasis from neuroendocrine carcinoma of the cervix: illustrative case'. Together they form a unique fingerprint.

Cite this