Leishmania donovani infection of a susceptible host results in CD4+ T- cell apoptosis and decreased Th1 cytokine production

G. Das, H. Vohra, K. Rao, B. Saha, G. C. Mishra

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The disease visceral leishmaniasis is caused by a protozoan parasite, Leishmania donovani and is characterized by depressed cell-mediated immunity (CMI) and unhindered parasite growth in a susceptible host. The opposite trend is observed in a resistant host. However, the mechanism of this loss of CMI during the progressive disease is unknown as yet. In this report, we demonstrate that more than 40% of CD4+ T cells from a susceptible host undergo apoptosis resulting in a significant decrease in interleukin (IL)-2 and interferon (IFN)-γ secretion, leaving IL-4 secretion unaffected. These changes are not apparent in the case of CD4+ T cells derived from a resistant host. The data reported here suggest that experimental Leishmania donovani infection leads to selective deletion of the IL-2 and IFN-γ- secreting cells but not Th2-like cells in a susceptible but not a resistant host.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalScandinavian Journal of Immunology
Volume49
Issue number3
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Immunology

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