Legionella pneumophila: Growth inhibition by human pharyngeal flora

A. R. Flesher, D. L. Kasper, P. A. Modern, E. O. Mason

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Several bacteria isolated from human pharyngeal cultures specifically inhibited the growth of Legionella pneumophila. The inhibitory substance from two strains (Streptococcus species 1-3 and Staphylococcus saprophyticus KC) was isolated from a broth supernatant. The inhibitor was active against all strains of L. pneumophila tested, including five strains of L. pneumophila serogroup 1 and one strain each of serogroups 2, 3, and 4. The substance did not inhibit growth of 18 fresh clinical and laboratory pathogens (12 genera). The substance was dialyzable, was resistant to heat and proteolysis, and did not precipitate with ammonium sulfate. Nicotinamide adenine dinucleotide, produced by several upper respiratory tract organisms, did not inhibit L. pneumophila, and L. pneumophila could not be isolated when Streptococcus species 1-3, S. saprophyticus KC, and L. pneumophila were cocultivated. These properties may in part explain the difficulty of isolation and may aid in the identification of L. pneumophila.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalJournal of Infectious Diseases
Volume142
Issue number3
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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