Left ventricular mass on positron emission tomography: Validation against cardiovascular magnetic resonance

Maan Malahfji, Ahmed Ibrahim Ahmed, Yushui Han, Aaron K. Jung, Talal Alnabelsi, Faisal Nabi, Dipan J. Shah, Ahmed Aljizeeri, Alexis Poitrasson-Rivière, Edward Ficaro, John J. Mahmarian, Mouaz H. Al-Mallah

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


BACKGROUND: Left ventricular hypertrophy (LVH) is an important clinical finding that is independently associated with mortality and cardiovascular events. We aimed to assess the interstudy variability of LV mass quantitation between PET and CMR.

METHODS: Patients who underwent both PET and CMR within 1 year were identified from prospective institutional registries. LV mass on PET was compared against LV mass on CMR using several statistical measures of agreement.

RESULTS: A total of 105 patients (mean age 60 ± 14 years, 67.6% male) were included. The median (interquartile range, IQR) duration between CMR and PET was 47 (11-154) days. The median (IQR) LV mass values were 168.0 g (126.0-202.0) on CMR and 174.0 g (150.0-212.0) with PET (absolute mean difference 29.42 ± 25.3). There was a good correlation (Spearman ρ = 0.81, P < 0.001; Intraclass Correlation Coefficient 0.78, 95% CI 0.70-0.85, P < 0.001) with moderate limits of agreement (95% limits of agreement - 63.78 to 83.7.) Results were consistent, albeit with moderate correlation, in subgroups of patients with LVH, in patients with myocardial infarction, in patients with LV ejection fraction < 50%, and those with limited image quality. LV mass on PET tended to be underestimated at high values compared to CMR.

CONCLUSION: We demonstrate good correlation and reproducibility of LV mass quantitation by PET against the reference standard of CMR across a wide range of normal and diseased hearts with a tendency of PET to underestimate mass at higher mass values.

Original languageEnglish (US)
Pages (from-to)1632-1642
Number of pages11
JournalJournal of Nuclear Cardiology
Issue number4
StatePublished - Aug 2022


  • CMR
  • PET
  • nuclear cardiac imaging
  • Reproducibility of Results
  • Prospective Studies
  • Magnetic Resonance Spectroscopy
  • Ventricular Function, Left
  • Humans
  • Middle Aged
  • Male
  • Hypertrophy, Left Ventricular/diagnostic imaging
  • Magnetic Resonance Imaging, Cine/methods
  • Stroke Volume
  • Female
  • Aged
  • Positron-Emission Tomography/methods

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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