Left ventricular hypertrophy by electrocardiography and echocardiography in the African American Study of Kidney Disease Cohort Study

Research output: Contribution to journalArticle

Ricardo Esquitin, Louai Razzouk, Gail E. Peterson, Jackson T. Wright, Robert A. Phillips, Tine L. De Backer, David A. Baran, Cynthia Kendrick, Tom Greene, James Reiffel, Paul Muntner, Michael E. Farkouh

Although electrocardiographic criteria for diagnosing left ventricular hypertrophy have a low sensitivity in the general population, their test characteristics have not been evaluated in the high-prevalence group of American Americans with chronic kidney disease. The purpose of the current study was to evaluate these test characteristics among African Americans (n = 645) with hypertensive kidney disease as part of the African-American Study of Kidney Disease and Hypertension cohort. Electrocardiograms were read by 2 cardiologists at an independent core laboratory using the 2 Sokolow-Lyon criteria and the Cornell criteria. Left ventricular hypertrophy on echocardiography was defined as left ventricular mass index greater than 49.2 and greater than 46.7 g/m 2.7 in men and women, respectively. Sixty-nine percent of the population had left ventricular hypertrophy on echo, whereas 34% had left ventricular hypertrophy by any of the electrocardiographic criteria. Sensitivity by individual electrocardiographic criteria was 16.5% by Sokolow-Lyon-1, 19.3% by Sokolow-Lyon-2, and 24.7% by Cornell criteria, with specificity ranging from 89% to 92%. When using any of the 3 criteria, sensitivity increased to 40.4% with a decrease in specificity to 78.0%. Consistent with findings in a general population, left ventricular hypertrophy by electrocardiography had low sensitivity and high specificity in this cohort of African Americans with hypertensive kidney disease.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalJournal of the American Society of Hypertension
Volume6
Issue number3
DOIs
StatePublished - May 1 2012

PMID: 22341790

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Left ventricular hypertrophy by electrocardiography and echocardiography in the African American Study of Kidney Disease Cohort Study. / Esquitin, Ricardo; Razzouk, Louai; Peterson, Gail E.; Wright, Jackson T.; Phillips, Robert A.; De Backer, Tine L.; Baran, David A.; Kendrick, Cynthia; Greene, Tom; Reiffel, James; Muntner, Paul; Farkouh, Michael E.

In: Journal of the American Society of Hypertension, Vol. 6, No. 3, 01.05.2012, p. 193-200.

Research output: Contribution to journalArticle

Harvard

Esquitin, R, Razzouk, L, Peterson, GE, Wright, JT, Phillips, RA, De Backer, TL, Baran, DA, Kendrick, C, Greene, T, Reiffel, J, Muntner, P & Farkouh, ME 2012, 'Left ventricular hypertrophy by electrocardiography and echocardiography in the African American Study of Kidney Disease Cohort Study' Journal of the American Society of Hypertension, vol. 6, no. 3, pp. 193-200. https://doi.org/10.1016/j.jash.2012.01.004

APA

Esquitin, R., Razzouk, L., Peterson, G. E., Wright, J. T., Phillips, R. A., De Backer, T. L., ... Farkouh, M. E. (2012). Left ventricular hypertrophy by electrocardiography and echocardiography in the African American Study of Kidney Disease Cohort Study. Journal of the American Society of Hypertension, 6(3), 193-200. https://doi.org/10.1016/j.jash.2012.01.004

Vancouver

Esquitin R, Razzouk L, Peterson GE, Wright JT, Phillips RA, De Backer TL et al. Left ventricular hypertrophy by electrocardiography and echocardiography in the African American Study of Kidney Disease Cohort Study. Journal of the American Society of Hypertension. 2012 May 1;6(3):193-200. https://doi.org/10.1016/j.jash.2012.01.004

Author

Esquitin, Ricardo ; Razzouk, Louai ; Peterson, Gail E. ; Wright, Jackson T. ; Phillips, Robert A. ; De Backer, Tine L. ; Baran, David A. ; Kendrick, Cynthia ; Greene, Tom ; Reiffel, James ; Muntner, Paul ; Farkouh, Michael E. / Left ventricular hypertrophy by electrocardiography and echocardiography in the African American Study of Kidney Disease Cohort Study. In: Journal of the American Society of Hypertension. 2012 ; Vol. 6, No. 3. pp. 193-200.

BibTeX

@article{5813f1c508bf4d449516540a2a275838,
title = "Left ventricular hypertrophy by electrocardiography and echocardiography in the African American Study of Kidney Disease Cohort Study",
abstract = "Although electrocardiographic criteria for diagnosing left ventricular hypertrophy have a low sensitivity in the general population, their test characteristics have not been evaluated in the high-prevalence group of American Americans with chronic kidney disease. The purpose of the current study was to evaluate these test characteristics among African Americans (n = 645) with hypertensive kidney disease as part of the African-American Study of Kidney Disease and Hypertension cohort. Electrocardiograms were read by 2 cardiologists at an independent core laboratory using the 2 Sokolow-Lyon criteria and the Cornell criteria. Left ventricular hypertrophy on echocardiography was defined as left ventricular mass index greater than 49.2 and greater than 46.7 g/m 2.7 in men and women, respectively. Sixty-nine percent of the population had left ventricular hypertrophy on echo, whereas 34{\%} had left ventricular hypertrophy by any of the electrocardiographic criteria. Sensitivity by individual electrocardiographic criteria was 16.5{\%} by Sokolow-Lyon-1, 19.3{\%} by Sokolow-Lyon-2, and 24.7{\%} by Cornell criteria, with specificity ranging from 89{\%} to 92{\%}. When using any of the 3 criteria, sensitivity increased to 40.4{\%} with a decrease in specificity to 78.0{\%}. Consistent with findings in a general population, left ventricular hypertrophy by electrocardiography had low sensitivity and high specificity in this cohort of African Americans with hypertensive kidney disease.",
keywords = "African American, Hypertension, echocardiography, electrocardiography, kidney disease, left ventricular hypertrophy",
author = "Ricardo Esquitin and Louai Razzouk and Peterson, {Gail E.} and Wright, {Jackson T.} and Phillips, {Robert A.} and {De Backer}, {Tine L.} and Baran, {David A.} and Cynthia Kendrick and Tom Greene and James Reiffel and Paul Muntner and Farkouh, {Michael E.}",
year = "2012",
month = "5",
day = "1",
doi = "10.1016/j.jash.2012.01.004",
language = "English (US)",
volume = "6",
pages = "193--200",
journal = "Journal of the American Society of Hypertension",
issn = "1933-1711",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Left ventricular hypertrophy by electrocardiography and echocardiography in the African American Study of Kidney Disease Cohort Study

AU - Esquitin, Ricardo

AU - Razzouk, Louai

AU - Peterson, Gail E.

AU - Wright, Jackson T.

AU - Phillips, Robert A.

AU - De Backer, Tine L.

AU - Baran, David A.

AU - Kendrick, Cynthia

AU - Greene, Tom

AU - Reiffel, James

AU - Muntner, Paul

AU - Farkouh, Michael E.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Although electrocardiographic criteria for diagnosing left ventricular hypertrophy have a low sensitivity in the general population, their test characteristics have not been evaluated in the high-prevalence group of American Americans with chronic kidney disease. The purpose of the current study was to evaluate these test characteristics among African Americans (n = 645) with hypertensive kidney disease as part of the African-American Study of Kidney Disease and Hypertension cohort. Electrocardiograms were read by 2 cardiologists at an independent core laboratory using the 2 Sokolow-Lyon criteria and the Cornell criteria. Left ventricular hypertrophy on echocardiography was defined as left ventricular mass index greater than 49.2 and greater than 46.7 g/m 2.7 in men and women, respectively. Sixty-nine percent of the population had left ventricular hypertrophy on echo, whereas 34% had left ventricular hypertrophy by any of the electrocardiographic criteria. Sensitivity by individual electrocardiographic criteria was 16.5% by Sokolow-Lyon-1, 19.3% by Sokolow-Lyon-2, and 24.7% by Cornell criteria, with specificity ranging from 89% to 92%. When using any of the 3 criteria, sensitivity increased to 40.4% with a decrease in specificity to 78.0%. Consistent with findings in a general population, left ventricular hypertrophy by electrocardiography had low sensitivity and high specificity in this cohort of African Americans with hypertensive kidney disease.

AB - Although electrocardiographic criteria for diagnosing left ventricular hypertrophy have a low sensitivity in the general population, their test characteristics have not been evaluated in the high-prevalence group of American Americans with chronic kidney disease. The purpose of the current study was to evaluate these test characteristics among African Americans (n = 645) with hypertensive kidney disease as part of the African-American Study of Kidney Disease and Hypertension cohort. Electrocardiograms were read by 2 cardiologists at an independent core laboratory using the 2 Sokolow-Lyon criteria and the Cornell criteria. Left ventricular hypertrophy on echocardiography was defined as left ventricular mass index greater than 49.2 and greater than 46.7 g/m 2.7 in men and women, respectively. Sixty-nine percent of the population had left ventricular hypertrophy on echo, whereas 34% had left ventricular hypertrophy by any of the electrocardiographic criteria. Sensitivity by individual electrocardiographic criteria was 16.5% by Sokolow-Lyon-1, 19.3% by Sokolow-Lyon-2, and 24.7% by Cornell criteria, with specificity ranging from 89% to 92%. When using any of the 3 criteria, sensitivity increased to 40.4% with a decrease in specificity to 78.0%. Consistent with findings in a general population, left ventricular hypertrophy by electrocardiography had low sensitivity and high specificity in this cohort of African Americans with hypertensive kidney disease.

KW - African American

KW - Hypertension

KW - echocardiography

KW - electrocardiography

KW - kidney disease

KW - left ventricular hypertrophy

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UR - http://www.scopus.com/inward/citedby.url?scp=84859965704&partnerID=8YFLogxK

U2 - 10.1016/j.jash.2012.01.004

DO - 10.1016/j.jash.2012.01.004

M3 - Article

VL - 6

SP - 193

EP - 200

JO - Journal of the American Society of Hypertension

T2 - Journal of the American Society of Hypertension

JF - Journal of the American Society of Hypertension

SN - 1933-1711

IS - 3

ER -

ID: 16832600