Left ventricular geometry and 24-h blood pressure profile in Cushing’s syndrome

Eleonora Avenatti, Andrea Rebellato, Andrea Iannaccone, Marialberta Battocchio, Francesca Dassie, Franco Veglio, Alberto Milan, Francesco Fallo

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Cushing’s syndrome (CS) is associated with cardiovascular disease. The impact of the hemodynamic load on left ventricular mass (LVM) in patients with CS is not well known. In fact, the effects of 24-h blood pressure (BP) load and BP circadian rhythm on cardiac structure and function have not been studied. Aim of the present study has thus been to assess the presence of cardiac remodeling in patients with newly diagnosed CS, combining evaluation of cardiac remodeling and assessment of BP burden derived by 24-h ambulatory blood pressure monitoring (ABPM). 25 patients (4 M, 21 F) with CS underwent echocardiography in order to assess cardiac morphology and geometry (relative wall thickness—RWT). As controls, 25 subjects similar for demographic characteristics and 24-h BP were used. CS Patients were similar to controls by age, sex, mean 24-h BP, and body mass index. There was a significant increase in left ventricular mass (LVM; 44.4 ± 14.7 vs. 36.9 ± 10 g/m2.7, p = 0.03) and a significant increase in RWT (0.46 ± 0.07 vs. 0.41 ± 0.08, p = 0.02) in CS patients compared to controls. The prevalence of CS patients with pressure non-dipping profile was greater than that of controls (56 vs. 16 %, p < 0.05), with no significant association with LVM or geometry. 24-h urinary cortisol was not associated with LVM (r = 0.1, p = 0.5) or RWT (r = 0.02, p = 0.89) in the CS group. In conclusion, LVM and the concentric pattern of the left ventricle are relatively independent from 24-h BP load and profile (dipping/non-dipping) in CS patients.

Original languageEnglish (US)
Pages (from-to)547-554
Number of pages8
JournalEndocrine
Volume55
Issue number2
DOIs
StatePublished - Feb 1 2017

Keywords

  • Ambulatory blood pressure/home blood pressure monitor
  • Cardiac remodeling
  • Cushing’s syndrome
  • Dipping profile
  • Secondary high blood pressure

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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