Left ventricular dysfunction: Effects of long-term enalapril therapy on remodeling

B. H. Greenberg, Miguel A. Quiñones, C. Koilpillai, M. Limacher, D. Shindler, C. Benedict, B. Shelton

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Doppler echocardiographic studies were carried out for 301 patients with left ventricular dysfunction who were randomized to placebo or enalapril so that a determination of the long-term effects of enalapril therapy on left ventricular structure and function could be made. Compared with placebo, enalapril resulted in a significant reduction in the mitral annular E-wave to A-wave velocity ratio, left ventricular end-diastolic and end-systolic volumes, left ventricular mass, and circumferential wall stress. Enalapril attenuated the remodeling process, which suggests that this mechanism is related to the beneficial effects of angiotensin-converting enzyme inhibitors on the clinical course of disease in patients with left ventricular dysfunction.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalCardiology Review
Volume13
Issue number7
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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