Left Ventricular Diastolic Function: Understanding Pathophysiology, Diagnosis, and Prognosis With Echocardiography

Sherif F. Nagueh

doi:10.1016/j.jcmg.2018.10.038

Left Ventricular Diastolic Function: Understanding Pathophysiology, Diagnosis, and Prognosis With Echocardiography

Sherif F. Nagueh

Research output: Contribution to journal › Review article › peer-review

159 Scopus citations

Abstract

Left ventricular diastolic function plays an important role in determining left ventricular filling and stroke volume. Abnormal diastolic function has been recognized in many cardiovascular diseases and is associated with worse outcomes, including total mortality and hospitalizations due to heart failure. Using echocardiography, it is possible to diagnose the presence of diastolic dysfunction and the pathophysiologic mechanisms involved as they affect left ventricular and left atrial structure and function. This review addresses the role of echocardiography in understanding the pathophysiology of diastolic dysfunction, its diagnosis, and utility in predicting outcomes.

Original language	English (US)
Pages (from-to)	228-244
Number of pages	17
Journal	JACC: Cardiovascular Imaging
Volume	13
Issue number	1 Pt 2
DOIs	https://doi.org/10.1016/j.jcmg.2018.10.038
State	Published - Jan 2020

Keywords

Doppler
diastole
echocardiography
filling pressure
left atrium
Predictive Value of Tests
Heart Failure/diagnostic imaging
Prognosis
Diastole
Ventricular Function, Left
Humans
Risk Factors
Ventricular Dysfunction, Left/diagnostic imaging
Disease Progression
Echocardiography, Doppler

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging

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10.1016/j.jcmg.2018.10.038

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title = "Left Ventricular Diastolic Function: Understanding Pathophysiology, Diagnosis, and Prognosis With Echocardiography",

abstract = "Left ventricular diastolic function plays an important role in determining left ventricular filling and stroke volume. Abnormal diastolic function has been recognized in many cardiovascular diseases and is associated with worse outcomes, including total mortality and hospitalizations due to heart failure. Using echocardiography, it is possible to diagnose the presence of diastolic dysfunction and the pathophysiologic mechanisms involved as they affect left ventricular and left atrial structure and function. This review addresses the role of echocardiography in understanding the pathophysiology of diastolic dysfunction, its diagnosis, and utility in predicting outcomes.",

keywords = "Doppler, diastole, echocardiography, filling pressure, left atrium, Predictive Value of Tests, Heart Failure/diagnostic imaging, Prognosis, Diastole, Ventricular Function, Left, Humans, Risk Factors, Ventricular Dysfunction, Left/diagnostic imaging, Disease Progression, Echocardiography, Doppler",

author = "Nagueh, {Sherif F.}",

year = "2020",

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doi = "10.1016/j.jcmg.2018.10.038",

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AU - Nagueh, Sherif F.

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N2 - Left ventricular diastolic function plays an important role in determining left ventricular filling and stroke volume. Abnormal diastolic function has been recognized in many cardiovascular diseases and is associated with worse outcomes, including total mortality and hospitalizations due to heart failure. Using echocardiography, it is possible to diagnose the presence of diastolic dysfunction and the pathophysiologic mechanisms involved as they affect left ventricular and left atrial structure and function. This review addresses the role of echocardiography in understanding the pathophysiology of diastolic dysfunction, its diagnosis, and utility in predicting outcomes.

AB - Left ventricular diastolic function plays an important role in determining left ventricular filling and stroke volume. Abnormal diastolic function has been recognized in many cardiovascular diseases and is associated with worse outcomes, including total mortality and hospitalizations due to heart failure. Using echocardiography, it is possible to diagnose the presence of diastolic dysfunction and the pathophysiologic mechanisms involved as they affect left ventricular and left atrial structure and function. This review addresses the role of echocardiography in understanding the pathophysiology of diastolic dysfunction, its diagnosis, and utility in predicting outcomes.

KW - Doppler

KW - diastole

KW - echocardiography

KW - filling pressure

KW - left atrium

KW - Predictive Value of Tests

KW - Heart Failure/diagnostic imaging

KW - Prognosis

KW - Diastole

KW - Ventricular Function, Left

KW - Humans

KW - Risk Factors

KW - Ventricular Dysfunction, Left/diagnostic imaging

KW - Disease Progression

KW - Echocardiography, Doppler

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U2 - 10.1016/j.jcmg.2018.10.038

DO - 10.1016/j.jcmg.2018.10.038

M3 - Review article

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AN - SCOPUS:85064081291

SN - 1936-878X

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JO - JACC: Cardiovascular Imaging

JF - JACC: Cardiovascular Imaging

IS - 1 Pt 2

ER -

Left Ventricular Diastolic Function: Understanding Pathophysiology, Diagnosis, and Prognosis With Echocardiography

Abstract

Keywords

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