Learning from natural design for local anesthetic delivery

Qing Sun, Guangjun Nie

Research output: Contribution to journalShort surveypeer-review


There is a sizeable but unfilled need for drug delivery systems that prolong the duration of action and reduce the systemic toxicity of local anesthetics. Inspired by the interactions of anesthetics with their natural binding sites on sodium channels, Ji et al. designed self-assembled nanostructures that achieve specific delivery and sustained release of anesthetics.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalTrends in Pharmacological Sciences
Issue number2
StatePublished - Feb 2022


  • controlled release system
  • local anesthetics
  • site-1 sodium channel blockers (S1SCBs)
  • specific delivery
  • supramolecular assembly

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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