Mitral regurgitation (MR) is the most prevalent valvular heart disease globally. Mitral valve surgery is the gold-standard treatment for MR. However, a significant portion of patients with mitral valve disease are at high or prohibitive surgical risk. Transcatheter mitral valve replacement (TMVR) has emerged as a potential treatment option for this vulnerable population. Numerous TMVR devices are currently being investigated, with early data demonstrating feasibility and efficacy of TMVR. In this article, we explore the unique challenges of designing a TMVR system and describe the TMVR systems under clinical evaluation.

Original languageEnglish (US)
JournalHeart International
Issue number2
StatePublished - 2021


  • Mitral regurgitation
  • Mitral valve replacement
  • Mitral valve surgery
  • Transcatheter mitral valve replacement
  • Transcatheter valve therapies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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