Late Electrocardiographic Changes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation

Research output: Contribution to journalArticle

Laurent Faroux, Guillem Muntané-Carol, Marina Urena, Luis Nombela-Franco, Ignacio Amat-Santos, Neal Kleiman, Antonio Munoz-Garcia, Felipe Atienza, Vicenç Serra, Marc W. Deyell, Gabriela Veiga-Fernandez, Jean Bernard Masson, Victoria Canadas-Godoy, Dominique Himbert, Quentin Fischer, Javier Castrodeza, Jaime Elizaga, Jaume Francisco Pascual, John G. Webb, Jose M. de la Torre & 6 others Lluis Asmarats, Emilie Pelletier-Beaumont, Marcel Alméndarez, Thomas Couture, Francois Philippon, Josep Rodes-Cabau

This study sought to determine, in patients with new-onset persistent left bundle branch block (NOP-LBBB) after transcatheter aortic valve implantation (TAVI), the incidence and factors associated with (i) LBBB recovery and (ii) permanent pacemaker implantation (PPI) at 1-year follow-up. This was a multicenter study including 153 patients (mean age: 81 ± 5 years, 56% of women) with NOP-LBBB post-TAVI (balloon-expandable valve in 112 patients). Delta PR (ΔPR) and delta QRS (ΔQRS) were defined as the difference in PR and QRS length between baseline and hospital discharge ECG, and the relative ΔPR and ΔQRS as absolute ΔPR and ΔQRS divided by baseline PR and QRS length, respectively. The patients had a clinical visit and 12-lead ECG at 1-year follow-up. LBBB recovery was observed in 50 patients (33%), and 14 patients (9%) had advanced conduction disturbances requiring PPI during the follow-up period. No clinical or ECG variables were associated with LBBB recovery, including prosthesis type (self- or balloon-expandable valve, p = 0.563), QRS width at baseline/discharge or absolute/relative ΔQRS (p >0.10 for all). The presence of atrial fibrillation at baseline (0.026), a longer PR interval at discharge (0.009), and a longer absolute and relative ΔPR (p = 0.002 and p = 0.004, respectively) were associated with an increased risk of PPI at 1-year follow-up. In conclusion, NOP-LBBB post-TAVI resolved in one-third of patients at 1-year follow-up, but no clinical or ECG variables were associated with LBBB recovery. Conversely, a nonsinus rhythm at baseline and a longer ΔPR were associated with an increased risk of PPI within the year after TAVI.

Original languageEnglish (US)
Pages (from-to)795-802
Number of pages8
JournalAmerican Journal of Cardiology
Volume125
Issue number5
DOIs
StatePublished - Mar 1 2020

PMID: 31889524

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Late Electrocardiographic Changes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation. / Faroux, Laurent; Muntané-Carol, Guillem; Urena, Marina; Nombela-Franco, Luis; Amat-Santos, Ignacio; Kleiman, Neal; Munoz-Garcia, Antonio; Atienza, Felipe; Serra, Vicenç; Deyell, Marc W.; Veiga-Fernandez, Gabriela; Masson, Jean Bernard; Canadas-Godoy, Victoria; Himbert, Dominique; Fischer, Quentin; Castrodeza, Javier; Elizaga, Jaime; Pascual, Jaume Francisco; Webb, John G.; de la Torre, Jose M.; Asmarats, Lluis; Pelletier-Beaumont, Emilie; Alméndarez, Marcel; Couture, Thomas; Philippon, Francois; Rodes-Cabau, Josep.

In: American Journal of Cardiology, Vol. 125, No. 5, 01.03.2020, p. 795-802.

Research output: Contribution to journalArticle

Harvard

Faroux, L, Muntané-Carol, G, Urena, M, Nombela-Franco, L, Amat-Santos, I, Kleiman, N, Munoz-Garcia, A, Atienza, F, Serra, V, Deyell, MW, Veiga-Fernandez, G, Masson, JB, Canadas-Godoy, V, Himbert, D, Fischer, Q, Castrodeza, J, Elizaga, J, Pascual, JF, Webb, JG, de la Torre, JM, Asmarats, L, Pelletier-Beaumont, E, Alméndarez, M, Couture, T, Philippon, F & Rodes-Cabau, J 2020, 'Late Electrocardiographic Changes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation' American Journal of Cardiology, vol. 125, no. 5, pp. 795-802. https://doi.org/10.1016/j.amjcard.2019.11.025

APA

Faroux, L., Muntané-Carol, G., Urena, M., Nombela-Franco, L., Amat-Santos, I., Kleiman, N., ... Rodes-Cabau, J. (2020). Late Electrocardiographic Changes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation. American Journal of Cardiology, 125(5), 795-802. https://doi.org/10.1016/j.amjcard.2019.11.025

Vancouver

Faroux L, Muntané-Carol G, Urena M, Nombela-Franco L, Amat-Santos I, Kleiman N et al. Late Electrocardiographic Changes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation. American Journal of Cardiology. 2020 Mar 1;125(5):795-802. https://doi.org/10.1016/j.amjcard.2019.11.025

Author

Faroux, Laurent ; Muntané-Carol, Guillem ; Urena, Marina ; Nombela-Franco, Luis ; Amat-Santos, Ignacio ; Kleiman, Neal ; Munoz-Garcia, Antonio ; Atienza, Felipe ; Serra, Vicenç ; Deyell, Marc W. ; Veiga-Fernandez, Gabriela ; Masson, Jean Bernard ; Canadas-Godoy, Victoria ; Himbert, Dominique ; Fischer, Quentin ; Castrodeza, Javier ; Elizaga, Jaime ; Pascual, Jaume Francisco ; Webb, John G. ; de la Torre, Jose M. ; Asmarats, Lluis ; Pelletier-Beaumont, Emilie ; Alméndarez, Marcel ; Couture, Thomas ; Philippon, Francois ; Rodes-Cabau, Josep. / Late Electrocardiographic Changes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation. In: American Journal of Cardiology. 2020 ; Vol. 125, No. 5. pp. 795-802.

BibTeX

@article{232671ec06a64e2f8ff6b30c0b987aff,
title = "Late Electrocardiographic Changes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation",
abstract = "This study sought to determine, in patients with new-onset persistent left bundle branch block (NOP-LBBB) after transcatheter aortic valve implantation (TAVI), the incidence and factors associated with (i) LBBB recovery and (ii) permanent pacemaker implantation (PPI) at 1-year follow-up. This was a multicenter study including 153 patients (mean age: 81 ± 5 years, 56{\%} of women) with NOP-LBBB post-TAVI (balloon-expandable valve in 112 patients). Delta PR (ΔPR) and delta QRS (ΔQRS) were defined as the difference in PR and QRS length between baseline and hospital discharge ECG, and the relative ΔPR and ΔQRS as absolute ΔPR and ΔQRS divided by baseline PR and QRS length, respectively. The patients had a clinical visit and 12-lead ECG at 1-year follow-up. LBBB recovery was observed in 50 patients (33{\%}), and 14 patients (9{\%}) had advanced conduction disturbances requiring PPI during the follow-up period. No clinical or ECG variables were associated with LBBB recovery, including prosthesis type (self- or balloon-expandable valve, p = 0.563), QRS width at baseline/discharge or absolute/relative ΔQRS (p >0.10 for all). The presence of atrial fibrillation at baseline (0.026), a longer PR interval at discharge (0.009), and a longer absolute and relative ΔPR (p = 0.002 and p = 0.004, respectively) were associated with an increased risk of PPI at 1-year follow-up. In conclusion, NOP-LBBB post-TAVI resolved in one-third of patients at 1-year follow-up, but no clinical or ECG variables were associated with LBBB recovery. Conversely, a nonsinus rhythm at baseline and a longer ΔPR were associated with an increased risk of PPI within the year after TAVI.",
author = "Laurent Faroux and Guillem Muntan{\'e}-Carol and Marina Urena and Luis Nombela-Franco and Ignacio Amat-Santos and Neal Kleiman and Antonio Munoz-Garcia and Felipe Atienza and Vicen{\cc} Serra and Deyell, {Marc W.} and Gabriela Veiga-Fernandez and Masson, {Jean Bernard} and Victoria Canadas-Godoy and Dominique Himbert and Quentin Fischer and Javier Castrodeza and Jaime Elizaga and Pascual, {Jaume Francisco} and Webb, {John G.} and {de la Torre}, {Jose M.} and Lluis Asmarats and Emilie Pelletier-Beaumont and Marcel Alm{\'e}ndarez and Thomas Couture and Francois Philippon and Josep Rodes-Cabau",
year = "2020",
month = "3",
day = "1",
doi = "10.1016/j.amjcard.2019.11.025",
language = "English (US)",
volume = "125",
pages = "795--802",
journal = "The American journal of cardiology",
issn = "0002-9149",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Late Electrocardiographic Changes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation

AU - Faroux, Laurent

AU - Muntané-Carol, Guillem

AU - Urena, Marina

AU - Nombela-Franco, Luis

AU - Amat-Santos, Ignacio

AU - Kleiman, Neal

AU - Munoz-Garcia, Antonio

AU - Atienza, Felipe

AU - Serra, Vicenç

AU - Deyell, Marc W.

AU - Veiga-Fernandez, Gabriela

AU - Masson, Jean Bernard

AU - Canadas-Godoy, Victoria

AU - Himbert, Dominique

AU - Fischer, Quentin

AU - Castrodeza, Javier

AU - Elizaga, Jaime

AU - Pascual, Jaume Francisco

AU - Webb, John G.

AU - de la Torre, Jose M.

AU - Asmarats, Lluis

AU - Pelletier-Beaumont, Emilie

AU - Alméndarez, Marcel

AU - Couture, Thomas

AU - Philippon, Francois

AU - Rodes-Cabau, Josep

PY - 2020/3/1

Y1 - 2020/3/1

N2 - This study sought to determine, in patients with new-onset persistent left bundle branch block (NOP-LBBB) after transcatheter aortic valve implantation (TAVI), the incidence and factors associated with (i) LBBB recovery and (ii) permanent pacemaker implantation (PPI) at 1-year follow-up. This was a multicenter study including 153 patients (mean age: 81 ± 5 years, 56% of women) with NOP-LBBB post-TAVI (balloon-expandable valve in 112 patients). Delta PR (ΔPR) and delta QRS (ΔQRS) were defined as the difference in PR and QRS length between baseline and hospital discharge ECG, and the relative ΔPR and ΔQRS as absolute ΔPR and ΔQRS divided by baseline PR and QRS length, respectively. The patients had a clinical visit and 12-lead ECG at 1-year follow-up. LBBB recovery was observed in 50 patients (33%), and 14 patients (9%) had advanced conduction disturbances requiring PPI during the follow-up period. No clinical or ECG variables were associated with LBBB recovery, including prosthesis type (self- or balloon-expandable valve, p = 0.563), QRS width at baseline/discharge or absolute/relative ΔQRS (p >0.10 for all). The presence of atrial fibrillation at baseline (0.026), a longer PR interval at discharge (0.009), and a longer absolute and relative ΔPR (p = 0.002 and p = 0.004, respectively) were associated with an increased risk of PPI at 1-year follow-up. In conclusion, NOP-LBBB post-TAVI resolved in one-third of patients at 1-year follow-up, but no clinical or ECG variables were associated with LBBB recovery. Conversely, a nonsinus rhythm at baseline and a longer ΔPR were associated with an increased risk of PPI within the year after TAVI.

AB - This study sought to determine, in patients with new-onset persistent left bundle branch block (NOP-LBBB) after transcatheter aortic valve implantation (TAVI), the incidence and factors associated with (i) LBBB recovery and (ii) permanent pacemaker implantation (PPI) at 1-year follow-up. This was a multicenter study including 153 patients (mean age: 81 ± 5 years, 56% of women) with NOP-LBBB post-TAVI (balloon-expandable valve in 112 patients). Delta PR (ΔPR) and delta QRS (ΔQRS) were defined as the difference in PR and QRS length between baseline and hospital discharge ECG, and the relative ΔPR and ΔQRS as absolute ΔPR and ΔQRS divided by baseline PR and QRS length, respectively. The patients had a clinical visit and 12-lead ECG at 1-year follow-up. LBBB recovery was observed in 50 patients (33%), and 14 patients (9%) had advanced conduction disturbances requiring PPI during the follow-up period. No clinical or ECG variables were associated with LBBB recovery, including prosthesis type (self- or balloon-expandable valve, p = 0.563), QRS width at baseline/discharge or absolute/relative ΔQRS (p >0.10 for all). The presence of atrial fibrillation at baseline (0.026), a longer PR interval at discharge (0.009), and a longer absolute and relative ΔPR (p = 0.002 and p = 0.004, respectively) were associated with an increased risk of PPI at 1-year follow-up. In conclusion, NOP-LBBB post-TAVI resolved in one-third of patients at 1-year follow-up, but no clinical or ECG variables were associated with LBBB recovery. Conversely, a nonsinus rhythm at baseline and a longer ΔPR were associated with an increased risk of PPI within the year after TAVI.

UR - http://www.scopus.com/inward/record.url?scp=85077171957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077171957&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2019.11.025

DO - 10.1016/j.amjcard.2019.11.025

M3 - Article

VL - 125

SP - 795

EP - 802

JO - The American journal of cardiology

T2 - The American journal of cardiology

JF - The American journal of cardiology

SN - 0002-9149

IS - 5

ER -

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