Laser interstitial thermal therapy for newly diagnosed and recurrent glioblastoma

Jonathan G. Thomas, Ganesh Rao, Yvonne Kew, Sujit S. Prabhu

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Objective Glioblastoma (GBM) is the most common and deadly malignant primary brain tumor. Better surgical therapies are needed for newly diagnosed GBMs that are difficult to resect and for GBMs that recur despite standard therapies. The authors reviewed their institutional experience of using laser interstitial thermal therapy (LITT) for the treatment of newly diagnosed or recurrent GBMs. Methods This study reports on the pre-LITT characteristics and post-LITT outcomes of 8 patients with newly diagnosed GBMs and 13 patients with recurrent GBM who underwent LITT. Results Compared with the group with recurrent GBMs, the patients with newly diagnosed GBMs who underwent LITT tended to be older (60.8 vs 48.9 years), harbored larger tumors (22.4 vs 14.6 cm3), and a greater proportion had IDH wild-type GBMs. In the newly diagnosed GBM group, the median progression-free survival and the median survival after the procedure were 2 months and 8 months, respectively, and no patient demonstrated radiographic shrinkage of the tumor on follow-up imaging. In the 13 patients with recurrent GBM, 5 demonstrated a response to LITT, with radiographic shrinkage of the tumor following ablation. The median progression-free survival was 5 months, and the median survival was greater than 7 months. Conc lusions In carefully selected patients with recurrent GBM, LITT may be an effective alternative to surgery as a salvage treatment. Its role in the treatment of newly diagnosed unresectable GBMs is not established yet and requires further study.

Original languageEnglish (US)
Article numberE12
JournalNeurosurgical focus
Volume41
Issue number4
DOIs
StatePublished - 2016

Keywords

  • GBM
  • Glioblastoma
  • LITT
  • Laser interstitial thermal therapy
  • Recurrence

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Laser interstitial thermal therapy for newly diagnosed and recurrent glioblastoma'. Together they form a unique fingerprint.

Cite this