Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma

K. Berlo, W. Xia, F. Zwillich, E. Gibbons, R. Gaudiuso, E. Ewusi-Annan, G. R. Chiklis, N. Melikechi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection and immune status is extremely urgently and critically needed. In this contribution we show that combining laser induced breakdown spectroscopy (LIBS) with machine learning can distinguish plasma of donors who previously tested positive for SARS-CoV-2 by RT-PCR from those who did not, with up to 95% accuracy. The samples were also analyzed by LIBS-ICP-MS in tandem mode, implicating a depletion of Zn and Ba in samples of SARS-CoV-2 positive subjects that inversely correlate with CN lines in the LIBS spectra.

Original languageEnglish (US)
Article number1614
JournalScientific Reports
Volume12
Issue number1
DOIs
StatePublished - Dec 2022

ASJC Scopus subject areas

  • General

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