Large cell calcifying Sertoli cell tumor of the testis: A clinicopathologic, immunohistochemical, and ultrastructural study of two cases

B. Tetu; Jae Ro; Alberto Ayala

doi:10.1093/ajcp/96.6.717

Large cell calcifying Sertoli cell tumor of the testis: A clinicopathologic, immunohistochemical, and ultrastructural study of two cases

B. Tetu, Jae Ro, Alberto Ayala

Research output: Contribution to journal › Article

27 Scopus citations

Abstract

The clinicopathologic, immunohistochemical, and electron microscopic study of two patients with large cell calcifying Sertoli cell tumors (LCCSCT) of the testis is reported to elucidate the histogenesis of this rare tumor. Both tumors occurred in young individuals (16 and 32 years); case 1 was found incidentally, and the patient in case 2 presented with a 3-4-week history of testicular pain. Evidence of testosterone production was demonstrated in one case. In the same case, at the ultrastructural level Charcot-Bottcher crystalloids were observed. These data support previous reports that LCCSCT shows Sertoli cell differentiation.

Original language	English (US)
Pages (from-to)	717-722
Number of pages	6
Journal	American Journal of Clinical Pathology
Volume	96
Issue number	6
DOIs	https://doi.org/10.1093/ajcp/96.6.717
State	Published - Jan 1 1991

Keywords

Charcot-Bottcher crystalloids
Sertoli cell tumor
Stromal cell tumor
Testicular neoplasm

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1093/ajcp/96.6.717

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title = "Large cell calcifying Sertoli cell tumor of the testis: A clinicopathologic, immunohistochemical, and ultrastructural study of two cases",

abstract = "The clinicopathologic, immunohistochemical, and electron microscopic study of two patients with large cell calcifying Sertoli cell tumors (LCCSCT) of the testis is reported to elucidate the histogenesis of this rare tumor. Both tumors occurred in young individuals (16 and 32 years); case 1 was found incidentally, and the patient in case 2 presented with a 3-4-week history of testicular pain. Evidence of testosterone production was demonstrated in one case. In the same case, at the ultrastructural level Charcot-Bottcher crystalloids were observed. These data support previous reports that LCCSCT shows Sertoli cell differentiation.",

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AB - The clinicopathologic, immunohistochemical, and electron microscopic study of two patients with large cell calcifying Sertoli cell tumors (LCCSCT) of the testis is reported to elucidate the histogenesis of this rare tumor. Both tumors occurred in young individuals (16 and 32 years); case 1 was found incidentally, and the patient in case 2 presented with a 3-4-week history of testicular pain. Evidence of testosterone production was demonstrated in one case. In the same case, at the ultrastructural level Charcot-Bottcher crystalloids were observed. These data support previous reports that LCCSCT shows Sertoli cell differentiation.

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