Large cell calcifying Sertoli cell tumor of the testis: A clinicopathologic, immunohistochemical, and ultrastructural study of two cases

The clinicopathologic, immunohistochemical, and electron microscopic study of two patients with large cell calcifying Sertoli cell tumors (LCCSCT) of the testis is reported to elucidate the histogenesis of this rare tumor. Both tumors occurred in young individuals (16 and 32 years); case 1 was found incidentally, and the patient in case 2 presented with a 3-4-week history of testicular pain. Evidence of testosterone production was demonstrated in one case. In the same case, at the ultrastructural level Charcot-Bottcher crystalloids were observed. These data support previous reports that LCCSCT shows Sertoli cell differentiation.