Lanthanide ion-doped GdPO4 nanorods with dual-modal bio-optical and magnetic resonance imaging properties

Wenlu Ren, Gan Tian, Liangjun Zhou, Wenyan Yin, Liang Yan, Shan Jin, Yan Zu, Shoujian Li, Zhanjun Gu, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Here, dual-modal bioprobes for combined optical and magnetic resonance (MR) imaging are reported. Gadolinium orthophosphate (GdPO4) nanorods co-doped with light-emitting lanthanide ions have been successfully prepared through a hydrothermal method. An efficient downconversion luminescence from Ce/Tb or Eu doped GdPO4 nanorods and upconversion luminescence from Yb/Er co-doped GdPO4 nanorods are observed, respectively, which offers the optical modality for the nanoprobes. Notably, we first report the upconversion phenomenon based on the GdPO4 matrix under 980 nm near infrared irradiation. The possibility of using these nanoprobes with downconversion and upconversion luminescent emissions for optical cell imaging is also demonstrated. Furthermore, these Gd3+-containing nanophosphors show good positive signal-enhancement ability when performed under a 4.7 T MR imaging scanner, indicating they have potential as T1 MR imaging contrast agents. Thus, nanoprobes based on GdPO4 nanophosphors are shown to provide the dual modality of optical and MR imaging. This journal is

Original languageEnglish (US)
Pages (from-to)3754-3760
Number of pages7
Issue number12
StatePublished - Jun 12 2012

ASJC Scopus subject areas

  • Materials Science(all)


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