Lanthanide-doped GdVO 4 upconversion nanophosphors with tunable emissions and their applications for biomedical imaging

Wenyan Yin, Liangjun Zhou, Zhanjun Gu, Gan Tian, Shan Jin, Liang Yan, Xiaoxiao Liu, Gengmei Xing, Wenlu Ren, Feng Liu, Zhengwei Pan, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Lanthanide ion doped GdVO 4 upconversion nanoparticles (UCNPs) have been synthesized via a simple hydrothermal process assisted with polyvinylpyrrolidone (PVP). The PVP had great effects on the morphology and luminescent intensity of the final products. Multicolor upconversion emissions such as orange, yellow, green and blue light can be generated by simply changing the codopant compositions or concentrations in these nanoparticles. A thin layer of silica was coated onto the surface of GdVO 4 UCNPs to form a core/shell structure in order to improve their biocompatibility. The applications of the low-toxicity, silica-coated GdVO 4 UCNPs as bio-tag for cell labeling and in vivo animal imaging were reported. In addition, the GdVO 4 nanoparticles showed high contrast T 1-enhancing modality due to the presence of Gd 3+ ions on the particle surface. Hence, this newly developed multicolor GdVO 4 UCNPs, which can be added into the upconversion nanomaterials family, could be used as a promising nanoprobe for dual-modality with optical bioimaging and magnetic resonance imaging (MRI).

Original languageEnglish (US)
Pages (from-to)6974-6981
Number of pages8
JournalJournal of Materials Chemistry
Volume22
Issue number14
DOIs
StatePublished - Apr 14 2012

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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