Landmark/image-based deformable registration of gene expression data

Uday Kurkure, Yen H. Le, Nikos Paragios, James P. Carson, Tao Ju, Ioannis A. Kakadiaris

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations


Analysis of gene expression patterns in brain images obtained from high-throughput in situ hybridization requires accurate and consistent annotations of anatomical regions/subregions. Such annotations are obtained by mapping an anatomical atlas onto the gene expression images through intensity- and/or landmark-based registration methods or deformable model-based segmentation methods. Due to the complex appearance of the gene expression images, these approaches require a pre-processing step to determine landmark correspondences in order to incorporate landmark-based geometric constraints. In this paper, we propose a novel method for landmark-constrained, intensity-based registration without determining landmark correspondences a priori. The proposed method performs dense image registration and identifies the landmark correspondences, simultaneously, using a single higher-order Markov Random Field model. In addition, a machine learning technique is used to improve the discriminating properties of local descriptors for landmark matching by projecting them in a Hamming space of lower dimension. We qualitatively show that our method achieves promising results and also compares well, quantitatively, with the expert's annotations, outperforming previous methods.

Original languageEnglish (US)
Title of host publication2011 IEEE Conference on Computer Vision and Pattern Recognition, CVPR 2011
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages8
ISBN (Print)9781457703942
StatePublished - 2011

Publication series

NameProceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition
ISSN (Print)1063-6919

ASJC Scopus subject areas

  • Software
  • Computer Vision and Pattern Recognition


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