Lactic Acid and Amino Acid Fluctuations Measured Using Microdialysis Reflect Physiological Derangements in Head Injury

J. C. Goodman, S. P. Gopinath, A. B. Valadka, R. K. Narayan, Robert G. Grossman, R. K. Simpson, C. S. Robertson

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We examined the extracellular neurochemical milieu in 34 head injured patients using microdialysis while simultaneously monitoring intracranial pressure, cerebral perfusion pressure, and jugular venous oxygen saturation. Derangements of anaerobic metabolism reflected by increased lactate and lactate/pyruvate ratios, and release of amino acids were seen at the same time as physiological deterioration in the majority of instances. Clinical microdialysis may provide insights into the neurochemistry of head injury, and such information may lead to new methods of monitoring and treating head injured patients.

Original languageEnglish (US)
Pages (from-to)37-39
Number of pages3
JournalActa Neurochirurgica, Supplement
Volume1996
Issue number67
DOIs
StatePublished - 1996

Keywords

  • Amino acids
  • Glutamate aspartate: Excitotoxicity
  • Head injury
  • Ischemia
  • Microdialysis: Lactic acid

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

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