Lack of depression effect on platelet activation in patients with heart failure

Jagoda Pasic, Mark D. Sullivan, Joan Russo, Wayne L. Chandler, Wayne C. Levy

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

P-selectin is a marker of platelet activation. Previous studies have reported elevated P-selectin in patients with congestive heart failure (CHF) and depression as separate disorders. We examined if comorbid depression had an effect on platelet activation in CHF patients. Soluble (s)P-selectin was measured in 108 CHF patients; 24 with comorbid depression. There were no significant differences in age, cardiac parameters or (s)P-selectin levels between CHF-only patients and patients with comorbid depression. Our data show no group differences in P-selectin values, which suggests that comorbid depression has no additive effect on platelet activation in CHF patient.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalPsychiatry Research
Volume129
Issue number3
DOIs
StatePublished - Dec 30 2004

Keywords

  • Atherosclerosis
  • Cytokines
  • Endothelial processes
  • P-selectin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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