Lack of depression effect on platelet activation in patients with heart failure

Jagoda Pasic; Mark D. Sullivan; Joan Russo; Wayne L. Chandler; Wayne C. Levy

doi:10.1016/j.psychres.2004.09.008

Lack of depression effect on platelet activation in patients with heart failure

Jagoda Pasic, Mark D. Sullivan, Joan Russo, Wayne L. Chandler, Wayne C. Levy

Houston Methodist

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

P-selectin is a marker of platelet activation. Previous studies have reported elevated P-selectin in patients with congestive heart failure (CHF) and depression as separate disorders. We examined if comorbid depression had an effect on platelet activation in CHF patients. Soluble (s)P-selectin was measured in 108 CHF patients; 24 with comorbid depression. There were no significant differences in age, cardiac parameters or (s)P-selectin levels between CHF-only patients and patients with comorbid depression. Our data show no group differences in P-selectin values, which suggests that comorbid depression has no additive effect on platelet activation in CHF patient.

Original language	English (US)
Pages (from-to)	289-292
Number of pages	4
Journal	Psychiatry Research
Volume	129
Issue number	3
DOIs	https://doi.org/10.1016/j.psychres.2004.09.008
State	Published - Dec 30 2004

Keywords

Atherosclerosis
Cytokines
Endothelial processes
P-selectin

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Psychology(all)

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10.1016/j.psychres.2004.09.008

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title = "Lack of depression effect on platelet activation in patients with heart failure",

abstract = "P-selectin is a marker of platelet activation. Previous studies have reported elevated P-selectin in patients with congestive heart failure (CHF) and depression as separate disorders. We examined if comorbid depression had an effect on platelet activation in CHF patients. Soluble (s)P-selectin was measured in 108 CHF patients; 24 with comorbid depression. There were no significant differences in age, cardiac parameters or (s)P-selectin levels between CHF-only patients and patients with comorbid depression. Our data show no group differences in P-selectin values, which suggests that comorbid depression has no additive effect on platelet activation in CHF patient.",

keywords = "Atherosclerosis, Cytokines, Endothelial processes, P-selectin",

author = "Jagoda Pasic and Sullivan, {Mark D.} and Joan Russo and Chandler, {Wayne L.} and Levy, {Wayne C.}",

note = "Funding Information: This study was supported by the National Alliance for Research on Schizophrenia and Depression, the American Heart Association and the Charles A. Dana Foundation. Findings were presented in part at the XII World Congress of Psychiatry, Yokohama, Japan, August 24–29, 2002.",

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AU - Pasic, Jagoda

AU - Sullivan, Mark D.

AU - Russo, Joan

AU - Chandler, Wayne L.

AU - Levy, Wayne C.

N1 - Funding Information: This study was supported by the National Alliance for Research on Schizophrenia and Depression, the American Heart Association and the Charles A. Dana Foundation. Findings were presented in part at the XII World Congress of Psychiatry, Yokohama, Japan, August 24–29, 2002.

PY - 2004/12/30

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N2 - P-selectin is a marker of platelet activation. Previous studies have reported elevated P-selectin in patients with congestive heart failure (CHF) and depression as separate disorders. We examined if comorbid depression had an effect on platelet activation in CHF patients. Soluble (s)P-selectin was measured in 108 CHF patients; 24 with comorbid depression. There were no significant differences in age, cardiac parameters or (s)P-selectin levels between CHF-only patients and patients with comorbid depression. Our data show no group differences in P-selectin values, which suggests that comorbid depression has no additive effect on platelet activation in CHF patient.

AB - P-selectin is a marker of platelet activation. Previous studies have reported elevated P-selectin in patients with congestive heart failure (CHF) and depression as separate disorders. We examined if comorbid depression had an effect on platelet activation in CHF patients. Soluble (s)P-selectin was measured in 108 CHF patients; 24 with comorbid depression. There were no significant differences in age, cardiac parameters or (s)P-selectin levels between CHF-only patients and patients with comorbid depression. Our data show no group differences in P-selectin values, which suggests that comorbid depression has no additive effect on platelet activation in CHF patient.

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KW - Cytokines

KW - Endothelial processes

KW - P-selectin

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Lack of depression effect on platelet activation in patients with heart failure

Abstract

Keywords

ASJC Scopus subject areas

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