Lack of acute cyclosporine nephrotoxicity in late heart-transplant recipients

François Piquard; Bernard Geny; Hélène Hardy; Nabil Chakfe; Bertrand Mettauer; Anne Charloux; Eliane Lampert; Jean Lonsdorfer

doi:10.1016/S1053-2498(00)00092-9

Lack of acute cyclosporine nephrotoxicity in late heart-transplant recipients

François Piquard, Bernard Geny, Hélène Hardy, Nabil Chakfe, Bertrand Mettauer, Anne Charloux, Eliane Lampert, Jean Lonsdorfer

Houston Methodist

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Cyclosporine induces daily renal hypoperfusion in subjects with normal atrial natriuretic peptide (ANP) levels, but its acute effects in heart transplant patients with increased ANP remain to be determined. Methods: Cyclosporinemia and creatinine clearance were monitored during 7 hours following cyclosporine administration in 6 heart transplant patients. Results-conclusions: No acute cyclosporine-induced decrease in creatinine clearance was observed after heart transplantation. These data suggest that maintenance cyclosporine dose may be less nephrotoxic than suspected and that increased ANP might protect the renal function late after heart transplantation. Copyright (C) 2000 International Society for Heart and Lung Transplantation.

Original language	English (US)
Pages (from-to)	507-509
Number of pages	3
Journal	Journal of Heart and Lung Transplantation
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/S1053-2498(00)00092-9
State	Published - May 2000

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine
Transplantation

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10.1016/S1053-2498(00)00092-9

Cite this

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title = "Lack of acute cyclosporine nephrotoxicity in late heart-transplant recipients",

abstract = "Background: Cyclosporine induces daily renal hypoperfusion in subjects with normal atrial natriuretic peptide (ANP) levels, but its acute effects in heart transplant patients with increased ANP remain to be determined. Methods: Cyclosporinemia and creatinine clearance were monitored during 7 hours following cyclosporine administration in 6 heart transplant patients. Results-conclusions: No acute cyclosporine-induced decrease in creatinine clearance was observed after heart transplantation. These data suggest that maintenance cyclosporine dose may be less nephrotoxic than suspected and that increased ANP might protect the renal function late after heart transplantation. Copyright (C) 2000 International Society for Heart and Lung Transplantation.",

author = "Fran{\c c}ois Piquard and Bernard Geny and H{\'e}l{\`e}ne Hardy and Nabil Chakfe and Bertrand Mettauer and Anne Charloux and Eliane Lampert and Jean Lonsdorfer",

note = "Funding Information: This study was supported in part by grants of the Faculty of Medicine and the H{\^o}pitaux Universitaires of Strasbourg. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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doi = "10.1016/S1053-2498(00)00092-9",

language = "English (US)",

volume = "19",

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TY - JOUR

T1 - Lack of acute cyclosporine nephrotoxicity in late heart-transplant recipients

AU - Piquard, François

AU - Geny, Bernard

AU - Hardy, Hélène

AU - Chakfe, Nabil

AU - Mettauer, Bertrand

AU - Charloux, Anne

AU - Lampert, Eliane

AU - Lonsdorfer, Jean

N1 - Funding Information: This study was supported in part by grants of the Faculty of Medicine and the Hôpitaux Universitaires of Strasbourg. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 2000/5

Y1 - 2000/5

N2 - Background: Cyclosporine induces daily renal hypoperfusion in subjects with normal atrial natriuretic peptide (ANP) levels, but its acute effects in heart transplant patients with increased ANP remain to be determined. Methods: Cyclosporinemia and creatinine clearance were monitored during 7 hours following cyclosporine administration in 6 heart transplant patients. Results-conclusions: No acute cyclosporine-induced decrease in creatinine clearance was observed after heart transplantation. These data suggest that maintenance cyclosporine dose may be less nephrotoxic than suspected and that increased ANP might protect the renal function late after heart transplantation. Copyright (C) 2000 International Society for Heart and Lung Transplantation.

AB - Background: Cyclosporine induces daily renal hypoperfusion in subjects with normal atrial natriuretic peptide (ANP) levels, but its acute effects in heart transplant patients with increased ANP remain to be determined. Methods: Cyclosporinemia and creatinine clearance were monitored during 7 hours following cyclosporine administration in 6 heart transplant patients. Results-conclusions: No acute cyclosporine-induced decrease in creatinine clearance was observed after heart transplantation. These data suggest that maintenance cyclosporine dose may be less nephrotoxic than suspected and that increased ANP might protect the renal function late after heart transplantation. Copyright (C) 2000 International Society for Heart and Lung Transplantation.

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Lack of acute cyclosporine nephrotoxicity in late heart-transplant recipients

Abstract

ASJC Scopus subject areas

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