TY - JOUR
T1 - Labeling and tracking cells with gold nanoparticles
AU - Chandrasekaran, Ramya
AU - Madheswaran, Thiagarajan
AU - Tharmalingam, Nagendran
AU - Bose, Rajendran JC
AU - Park, Hansoo
AU - Ha, Don Hyung
N1 - Funding Information:
This work was supported by the Creative Materials Discovery Program through the National Research Foundation (NRF) of Korea, funded by the Ministry of Science and ICT ( NRF-2018M3D1A1058813 ) and the NRF of Korea grant funded by the Ministry of Science and ICT ( NRF-2019R1A2C1007088 ).
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/1
Y1 - 2021/1
N2 - Gold nanoparticles (AuNPs) have garnered much attention as contrast agents for computerized tomography (CT) because of their facile synthesis and surface functionalization, in addition to their significant X-ray attenuation and minimal cytotoxicity. Cell labeling using AuNPs and tracking of the labeled cells using CT has become a time-efficient and cost-effective method. Actively targeted AuNPs can enhance CT contrast and sensitivity, and further reduce the radiation dosage needed during CT imaging. In this review, we summarize the state-of-the-art use of AuNPs in CT for cell tracking, including the precautionary steps necessary for their use and the difficulty in translating the process into clinical use.
AB - Gold nanoparticles (AuNPs) have garnered much attention as contrast agents for computerized tomography (CT) because of their facile synthesis and surface functionalization, in addition to their significant X-ray attenuation and minimal cytotoxicity. Cell labeling using AuNPs and tracking of the labeled cells using CT has become a time-efficient and cost-effective method. Actively targeted AuNPs can enhance CT contrast and sensitivity, and further reduce the radiation dosage needed during CT imaging. In this review, we summarize the state-of-the-art use of AuNPs in CT for cell tracking, including the precautionary steps necessary for their use and the difficulty in translating the process into clinical use.
KW - Cell Tracking/methods
KW - Contrast Media/pharmacology
KW - Gold Radioisotopes/pharmacology
KW - Humans
KW - Metal Nanoparticles/therapeutic use
KW - Nanotechnology/trends
KW - Tomography, X-Ray Computed/methods
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U2 - 10.1016/j.drudis.2020.10.020
DO - 10.1016/j.drudis.2020.10.020
M3 - Review article
C2 - 33130336
SN - 1359-6446
VL - 26
SP - 94
EP - 105
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 1
ER -