Label-free optical imaging for brain cancer assessment

Raksha Raghunathan, Matthew Vasquez, Katherine Zhang, Hong Zhao, Stephen T.C. Wong

Research output: Contribution to journalReview articlepeer-review


Advances in label-free optical imaging offer a promising avenue for brain cancer assessment, providing high-resolution, real-time insights without the need for radiation or exogeneous agents. These cost-effective and intricately detailed techniques overcome the limitations inherent in magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) scans by offering superior resolution and more readily accessible imaging options. This comprehensive review explores a variety of such methods, including photoacoustic imaging (PAI), optical coherence tomography (OCT), Raman imaging, and IR microscopy. It focuses on their roles in the detection, diagnosis, and management of brain tumors. By highlighting recent advances in these imaging techniques, the review aims to underscore the importance of label-free optical imaging in enhancing early detection and refining therapeutic strategies for brain cancer.

Original languageEnglish (US)
Pages (from-to)557-570
Number of pages14
JournalTrends in Cancer
Issue number6
StatePublished - Jun 2024


  • IR microscopy
  • Raman imaging
  • brain cancer
  • label-free optical imaging
  • optical coherence tomography
  • photoacoustic imaging

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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