l-Homoserine hydroxamic acid as an antitumor agent

Samuel Natelson, Panayotis Pantazis, Ethan Natelson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

This report confirms the potent mutagenic and antitumor activity of l-homoserine hydroxamic acid in both in vitro and in vivo test systems. Its mutagenic potential is evident in the developing tadpoles of Xenopus laevis eggs exposed to the compound. Cytotoxic effects are demonstrated against human leukemia and melanoma cell lines proliferating in tissue culture and against xenografts of human breast cancer and sarcoma growing in nude mice. We propose that the mutagenic and antitumor activity are mediated through hydroxylamine, which is released from its stable carrier amino acid, homoserine, consequent to a reduction in pH occurring at the cellular level. The cytotoxic effects of l-homoserine hydroxamic acid are more intense than those of the D-isomer and are more evident in neoplastic than in normal cell lines.

Original languageEnglish (US)
Pages (from-to)133-145
Number of pages13
JournalClinica Chimica Acta
Volume229
Issue number1-2
DOIs
StatePublished - Jan 1 1994

Keywords

  • Homoserine hydroxamic acid
  • Hydroxylamine
  • Leukemia
  • Melanoma
  • Mutagenesis
  • Nude mice

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry

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