Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

Xue Wei Wang, Shu Guang Yang, Chi Zhang, Ming Wen Hu, Jiang Qian, Jin Jin Ma, Yingchi Zhang, Bin Bin Yang, Yi Lan Weng, Guo Li Ming, Anish R. Kosanam, Saijilafu, Feng Quan Zhou

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Although modulating the neuronal cytoskeleton has been deemed a promising approach to enhance mammalian axon regeneration, only a few studies have shown convincing results, especially in the central nervous system. Wang et al. demonstrate that the deletion of non-muscle myosin II sufficiently induces significant mammalian CNS axon regeneration in vivo.

Original languageEnglish (US)
Article number107537
JournalCell Reports
Volume31
Issue number3
DOIs
StatePublished - Apr 21 2020

Keywords

  • Lin28
  • axon regeneration
  • cytoskeleton
  • growth cone
  • non-muscle myosin II
  • optic nerve regeneration
  • post-injury treatment
  • retinal ganglion cells
  • retraction bulb

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Wang, X. W., Yang, S. G., Zhang, C., Hu, M. W., Qian, J., Ma, J. J., Zhang, Y., Yang, B. B., Weng, Y. L., Ming, G. L., Kosanam, A. R., Saijilafu, & Zhou, F. Q. (2020). Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration. Cell Reports, 31(3), [107537]. https://doi.org/10.1016/j.celrep.2020.107537