TY - JOUR
T1 - Kinetic characterization of a novel cationic 99mTc(I)- tricarbonyl complex, 99mTc-15C5-PNP, for myocardial perfusion imaging
AU - Liu, Zhonglin
AU - Chen, Liying
AU - Liu, Shuang
AU - Barber, Christy
AU - Stevenson, Gail D.
AU - Furenlid, Lars R.
AU - Barrett, Harrison H.
AU - Woolfenden, James M.
N1 - Funding Information:
This work was supported by NIBIB Grant P41-EB002035. The authors have indicated they have no financial conflicts of interest.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/10
Y1 - 2010/10
N2 - Background: Intense liver uptake of 99mTc-sestamibi (MIBI) often interferes with visualization of myocardial perfusion in the inferior wall of the left ventricle. To develop improved myocardial perfusion agents, crown ether-containing dithiocarbamates and bisphosphines have been introduced in recent years. This study was designed to investigate the myocardial imaging properties and in vivo kinetics of a cationic 99mTc(I)-tricarbonyl complex, 99mTc-15C5-PNP, in comparison with MIBI. Methods: Dynamic cardiac images were acquired for 60 minutes after intravenous tracer injection using a small-animal SPECT system in healthy control rats and rats with myocardial infarcts. Myocardial and liver time-activity curves were generated for radiopharmaceutical kinetic analysis. Results: Good visualization of the left ventricular wall and perfusion defects could be achieved 20 minutes after 99mTc-15C5-PNP administration. 99mTc-15C5-PNP images in all hearts with infarcts showed perfusion defects, which were comparable to MIBI images. The kinetic curves plotted from 1 to 60 minutes demonstrated that 99mTc-15C5-PNP has a shorter washout half-life (6.4 ± 3.2 vs 124 ± 30.5 minutes, P < .01) in the liver, lower residual liver activity (14.5 ± 10.2% vs 36.5 ± 28.9%, P < .01), and higher heart/liver ratio than MIBI. Conclusions: 99mTc-15C5-PNP has potential for rapid myocardial perfusion imaging with low liver uptake.
AB - Background: Intense liver uptake of 99mTc-sestamibi (MIBI) often interferes with visualization of myocardial perfusion in the inferior wall of the left ventricle. To develop improved myocardial perfusion agents, crown ether-containing dithiocarbamates and bisphosphines have been introduced in recent years. This study was designed to investigate the myocardial imaging properties and in vivo kinetics of a cationic 99mTc(I)-tricarbonyl complex, 99mTc-15C5-PNP, in comparison with MIBI. Methods: Dynamic cardiac images were acquired for 60 minutes after intravenous tracer injection using a small-animal SPECT system in healthy control rats and rats with myocardial infarcts. Myocardial and liver time-activity curves were generated for radiopharmaceutical kinetic analysis. Results: Good visualization of the left ventricular wall and perfusion defects could be achieved 20 minutes after 99mTc-15C5-PNP administration. 99mTc-15C5-PNP images in all hearts with infarcts showed perfusion defects, which were comparable to MIBI images. The kinetic curves plotted from 1 to 60 minutes demonstrated that 99mTc-15C5-PNP has a shorter washout half-life (6.4 ± 3.2 vs 124 ± 30.5 minutes, P < .01) in the liver, lower residual liver activity (14.5 ± 10.2% vs 36.5 ± 28.9%, P < .01), and higher heart/liver ratio than MIBI. Conclusions: 99mTc-15C5-PNP has potential for rapid myocardial perfusion imaging with low liver uptake.
KW - Tc(I)-Tricarbonyl complex
KW - heart
KW - ischemia
KW - rat
KW - SPECT
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U2 - 10.1007/s12350-010-9262-y
DO - 10.1007/s12350-010-9262-y
M3 - Article
C2 - 20669059
AN - SCOPUS:77956947286
SN - 1071-3581
VL - 17
SP - 858
EP - 867
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
IS - 5
ER -