TY - JOUR
T1 - Kidney transplantation from donors after brain or cardiac death in China - A clinical analysis of 94 cases
AU - Wang, C.
AU - Liu, L.
AU - Fu, Q.
AU - Meng, F.
AU - Li, J.
AU - Deng, S.
AU - Fei, J.
AU - Yuan, X.
AU - Han, M.
AU - Chen, L.
AU - Qiu, J.
AU - Chen, G.
AU - Wang, H.
AU - Huo, F.
AU - Li, J.
AU - Lin, M.
AU - He, X.
N1 - Funding Information:
This study was supported by the National High Technology Research and Development Program of China (863 Program, 2012AA021008 ), the Key Clinical Project from the Ministry of Health ( 2010159 ), the National Natural Science Foundation of China ( 30972951 , 81170448 ), the Special Fund for Science Research by Ministry of Health ( 201002004 ), the Science and Technology Planning Key Clinical Project of Guangdong Province ( 2011A030400005 ), Science and Technology Planning Project of Guangdong Province ( 2010B031600236 ), Research Foundation of Organ Transplantation from Ministry of Public Health ( IHECC07-201009 ), Guangdong Natural Science Foundation ( S2011010004857 ) and Project by Division of Medical Service Management of Ministry of Health (2010).
PY - 2013/5
Y1 - 2013/5
N2 - Background: We analyzed outcomes of kidney transplantation (KTx) from donation after brain death (DBD) or cardiac death (DCD) in China under the current level of the health care system. Methods: Among 94 KTx performed from February 2007 to March 2012 in two organ transplant centers in the south of China, 50 KTx were used DBD and 44 DCD donors. We retrospectively analyzed the clinical outcomes. Results: At a mean follow-up of 25.5 months, the 1-year and 2-year graft survival rates were 96.8% and 95.2% respectively. Delayed graft function (DGF) occurred in 27.7% recipients, three of whom lost graft function. Among six observed acute rejection episodes, five were reversed. When compared to the DCD group in DBD patients were apt to recover from DGF. Serum creatinine decreased more promptly in the DBD than in DCD group. Serum creatinine in the DCD group increased after months 12, when it was significantly higher than that in the DBD group (P <.05). Conclusions: Kidney transplantation from DBD donors showed good outcomes with few complications. Although KTx from DCD donors showed a higher DGF rate and longer duration of graft recovery, we achieved favorable short-term clinical outcome using this source.
AB - Background: We analyzed outcomes of kidney transplantation (KTx) from donation after brain death (DBD) or cardiac death (DCD) in China under the current level of the health care system. Methods: Among 94 KTx performed from February 2007 to March 2012 in two organ transplant centers in the south of China, 50 KTx were used DBD and 44 DCD donors. We retrospectively analyzed the clinical outcomes. Results: At a mean follow-up of 25.5 months, the 1-year and 2-year graft survival rates were 96.8% and 95.2% respectively. Delayed graft function (DGF) occurred in 27.7% recipients, three of whom lost graft function. Among six observed acute rejection episodes, five were reversed. When compared to the DCD group in DBD patients were apt to recover from DGF. Serum creatinine decreased more promptly in the DBD than in DCD group. Serum creatinine in the DCD group increased after months 12, when it was significantly higher than that in the DBD group (P <.05). Conclusions: Kidney transplantation from DBD donors showed good outcomes with few complications. Although KTx from DCD donors showed a higher DGF rate and longer duration of graft recovery, we achieved favorable short-term clinical outcome using this source.
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U2 - 10.1016/j.transproceed.2013.01.083
DO - 10.1016/j.transproceed.2013.01.083
M3 - Article
C2 - 23726563
AN - SCOPUS:84878568279
SN - 0041-1345
VL - 45
SP - 1323
EP - 1326
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 4
ER -