Kidney injury associated with telavancin dosing regimen in an animal model

Vincent H. Tam; Kimberly R. Ledesma; Dana R. Bowers; Jian Zhou; Luan D. Truong

doi:10.1128/AAC.05002-14

Kidney injury associated with telavancin dosing regimen in an animal model

Vincent H. Tam, Kimberly R. Ledesma, Dana R. Bowers, Jian Zhou, Luan D. Truong

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The elevation of serum creatinine levels is a concern with telavancin therapy. We examined the onset of kidney injury associated with telavancin in an animal model. Urine samples were collected at baseline and daily to determine the concentrations of kidney injury molecule 1 (KIM-1), a marker for early kidney injury. When a clinically relevant exposure of telavancin was given daily to rats, some differences in kidney injury were attributed to the dosing regimen. Further investigations of alternative telavancin dosing regimens are warranted.

Original language	English (US)
Pages (from-to)	2930-2933
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	5
DOIs	https://doi.org/10.1128/AAC.05002-14
State	Published - May 1 2015

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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AB - The elevation of serum creatinine levels is a concern with telavancin therapy. We examined the onset of kidney injury associated with telavancin in an animal model. Urine samples were collected at baseline and daily to determine the concentrations of kidney injury molecule 1 (KIM-1), a marker for early kidney injury. When a clinically relevant exposure of telavancin was given daily to rats, some differences in kidney injury were attributed to the dosing regimen. Further investigations of alternative telavancin dosing regimens are warranted.

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Kidney injury associated with telavancin dosing regimen in an animal model

Abstract

ASJC Scopus subject areas

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