Kidney injury associated with telavancin dosing regimen in an animal model

Vincent H. Tam, Kimberly R. Ledesma, Dana R. Bowers, Jian Zhou, Luan D. Truong

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The elevation of serum creatinine levels is a concern with telavancin therapy. We examined the onset of kidney injury associated with telavancin in an animal model. Urine samples were collected at baseline and daily to determine the concentrations of kidney injury molecule 1 (KIM-1), a marker for early kidney injury. When a clinically relevant exposure of telavancin was given daily to rats, some differences in kidney injury were attributed to the dosing regimen. Further investigations of alternative telavancin dosing regimens are warranted.

Original languageEnglish (US)
Pages (from-to)2930-2933
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number5
DOIs
StatePublished - May 1 2015

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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