Keratin-hydrotalcites hybrid films for drug delivery applications

Tamara Posati, Demetra Giuri, Morena Nocchetti, Anna Sagnella, Marzia Gariboldi, Claudia Ferroni, Giovanna Sotgiu, Greta Varchi, Roberto Zamboni, Annalisa Aluigi

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.

Original languageEnglish (US)
Pages (from-to)177-185
Number of pages9
JournalEuropean Polymer Journal
Volume105
DOIs
StatePublished - Aug 1 2018

Keywords

  • Composites
  • Cytocompatibility
  • Drug release
  • Hydrotalcytes
  • Keratin

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Polymers and Plastics
  • Organic Chemistry

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