Keratin-hydrotalcites hybrid films for drug delivery applications

Tamara Posati, Demetra Giuri, Morena Nocchetti, Anna Sagnella, Marzia Gariboldi, Claudia Ferroni, Giovanna Sotgiu, Greta Varchi, Roberto Zamboni, Annalisa Aluigi

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.

Original languageEnglish (US)
Pages (from-to)177-185
Number of pages9
JournalEuropean Polymer Journal
Volume105
DOIs
StatePublished - Aug 2018

Keywords

  • Composites
  • Cytocompatibility
  • Drug release
  • Hydrotalcytes
  • Keratin

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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