Keratin-hydrotalcites hybrid films for drug delivery applications

Tamara Posati; Demetra Giuri; Morena Nocchetti; Anna Sagnella; Marzia Gariboldi; Claudia Ferroni; Giovanna Sotgiu; Greta Varchi; Roberto Zamboni; Annalisa Aluigi

doi:10.1016/j.eurpolymj.2018.05.030

Keratin-hydrotalcites hybrid films for drug delivery applications

Tamara Posati, Demetra Giuri, Morena Nocchetti, Anna Sagnella, Marzia Gariboldi, Claudia Ferroni, Giovanna Sotgiu, Greta Varchi, Roberto Zamboni, Annalisa Aluigi

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.

Original language	English (US)
Pages (from-to)	177-185
Number of pages	9
Journal	European Polymer Journal
Volume	105
DOIs	https://doi.org/10.1016/j.eurpolymj.2018.05.030
State	Published - Aug 2018

Keywords

Composites
Cytocompatibility
Drug release
Hydrotalcytes
Keratin

ASJC Scopus subject areas

Physics and Astronomy(all)
Polymers and Plastics
Organic Chemistry
Materials Chemistry

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10.1016/j.eurpolymj.2018.05.030

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title = "Keratin-hydrotalcites hybrid films for drug delivery applications",

abstract = "In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.",

keywords = "Composites, Cytocompatibility, Drug release, Hydrotalcytes, Keratin",

author = "Tamara Posati and Demetra Giuri and Morena Nocchetti and Anna Sagnella and Marzia Gariboldi and Claudia Ferroni and Giovanna Sotgiu and Greta Varchi and Roberto Zamboni and Annalisa Aluigi",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = aug,

doi = "10.1016/j.eurpolymj.2018.05.030",

language = "English (US)",

volume = "105",

pages = "177--185",

journal = "European Polymer Journal",

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T1 - Keratin-hydrotalcites hybrid films for drug delivery applications

AU - Posati, Tamara

AU - Giuri, Demetra

AU - Nocchetti, Morena

AU - Sagnella, Anna

AU - Gariboldi, Marzia

AU - Ferroni, Claudia

AU - Sotgiu, Giovanna

AU - Varchi, Greta

AU - Zamboni, Roberto

AU - Aluigi, Annalisa

PY - 2018/8

Y1 - 2018/8

N2 - In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.

AB - In this work novel hybrid materials for drug delivery purposes are obtained by combining keratin with hydrotalcite nanoparticles containing diclofenac. The hybrid films showed a less pronounced swelling, porosity and degradation and a greater thermal stability compared to pure keratin films containing free diclofenac. These results, together with the slight shift towards smaller wavelength numbers of amide I band led to the hypothesis of a probable cross-linking between hydrotalcites and the protein mediated by glutaraldehyde, which results in a total reinforcing action on the hybrid material. In addition, diclofenac release profiles of the hybrid film in physiological conditions were higher than those of the non-hybrid compound. Furthermore, keratin/hydrotalcite were able to support fibroblast cells adhesion and growth suggesting their potential use as drug delivery systems for wound healing and tissue engineering applications.

KW - Composites

KW - Cytocompatibility

KW - Drug release

KW - Hydrotalcytes

KW - Keratin

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U2 - 10.1016/j.eurpolymj.2018.05.030

DO - 10.1016/j.eurpolymj.2018.05.030

M3 - Article

AN - SCOPUS:85048597047

VL - 105

SP - 177

EP - 185

JO - European Polymer Journal

JF - European Polymer Journal

SN - 0014-3057

ER -

Keratin-hydrotalcites hybrid films for drug delivery applications

Abstract

Keywords

ASJC Scopus subject areas

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