TY - JOUR
T1 - Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis
AU - Sreedhar, Remya
AU - Arumugam, Somasundaram
AU - Karuppagounder, Vengadeshprabhu
AU - Thandavarayan, Rajarajan A.
AU - Giridharan, Vijayasree V.
AU - Pitchaimani, Vigneshwaran
AU - Afrin, Mst Rejina
AU - Harima, Meilei
AU - Nakamura, Takashi
AU - Nakamura, Masahiko
AU - Suzuki, Kenji
AU - Watanabe, Kenichi
N1 - Funding Information:
This research was supported by JSPS KAKENHI Grant (Number 26460239 ).
Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Jumihaidokuto, a Japanese kampo medicine, is prescribed in Japan for its anti-inflammatory activity. Here we have examined its beneficial effects against acute colitis induced by dextran sulfate sodium (DSS) in mice. We have used C57BL/6 female mice, divided into two groups and received 3% DSS in drinking water during the experimental period (8 days). Treatment group mice received 1 g/kg/day dose of Jumihaidokuto orally whereas DSS control group received equal volume of distilled water. Normal control group mice received plain drinking water. Jumihaidokuto treatment attenuated the colitis symptoms along with suppression of various inflammatory marker proteins such as IL-1β, IL-2Rα, IL-4, CTGF and RAGE. It has also down-regulated the oxidative stress and apoptotic signaling in the colons of mice with colitis. The present study has confirmed the beneficial effects of Jumihaidokuto on DSS induced acute colitis in mice and suggests that it can be a potential agent for the treatment of colitis.
AB - Jumihaidokuto, a Japanese kampo medicine, is prescribed in Japan for its anti-inflammatory activity. Here we have examined its beneficial effects against acute colitis induced by dextran sulfate sodium (DSS) in mice. We have used C57BL/6 female mice, divided into two groups and received 3% DSS in drinking water during the experimental period (8 days). Treatment group mice received 1 g/kg/day dose of Jumihaidokuto orally whereas DSS control group received equal volume of distilled water. Normal control group mice received plain drinking water. Jumihaidokuto treatment attenuated the colitis symptoms along with suppression of various inflammatory marker proteins such as IL-1β, IL-2Rα, IL-4, CTGF and RAGE. It has also down-regulated the oxidative stress and apoptotic signaling in the colons of mice with colitis. The present study has confirmed the beneficial effects of Jumihaidokuto on DSS induced acute colitis in mice and suggests that it can be a potential agent for the treatment of colitis.
KW - Colitis
KW - Inflammation
KW - Inflammatory bowel diseases
KW - Jumihaidokuto
KW - Oxidative stress
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U2 - 10.1016/j.intimp.2015.10.009
DO - 10.1016/j.intimp.2015.10.009
M3 - Article
C2 - 26548346
AN - SCOPUS:84948451754
VL - 29
SP - 957
EP - 963
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 2
ER -