Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis

Remya Sreedhar; Somasundaram Arumugam; Vengadeshprabhu Karuppagounder; Rajarajan A. Thandavarayan; Vijayasree V. Giridharan; Vigneshwaran Pitchaimani; Mst Rejina Afrin; Meilei Harima; Takashi Nakamura; Masahiko Nakamura; Kenji Suzuki; Kenichi Watanabe

doi:10.1016/j.intimp.2015.10.009

Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis

Remya Sreedhar, Somasundaram Arumugam, Vengadeshprabhu Karuppagounder, Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Vigneshwaran Pitchaimani, Mst Rejina Afrin, Meilei Harima, Takashi Nakamura, Masahiko Nakamura, Kenji Suzuki, Kenichi Watanabe

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Jumihaidokuto, a Japanese kampo medicine, is prescribed in Japan for its anti-inflammatory activity. Here we have examined its beneficial effects against acute colitis induced by dextran sulfate sodium (DSS) in mice. We have used C57BL/6 female mice, divided into two groups and received 3% DSS in drinking water during the experimental period (8 days). Treatment group mice received 1 g/kg/day dose of Jumihaidokuto orally whereas DSS control group received equal volume of distilled water. Normal control group mice received plain drinking water. Jumihaidokuto treatment attenuated the colitis symptoms along with suppression of various inflammatory marker proteins such as IL-1β, IL-2Rα, IL-4, CTGF and RAGE. It has also down-regulated the oxidative stress and apoptotic signaling in the colons of mice with colitis. The present study has confirmed the beneficial effects of Jumihaidokuto on DSS induced acute colitis in mice and suggests that it can be a potential agent for the treatment of colitis.

Original language	English (US)
Pages (from-to)	957-963
Number of pages	7
Journal	International Immunopharmacology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.intimp.2015.10.009
State	Published - Dec 1 2015

Keywords

Colitis
Inflammation
Inflammatory bowel diseases
Jumihaidokuto
Oxidative stress

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

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10.1016/j.intimp.2015.10.009

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Sreedhar, R., Arumugam, S., Karuppagounder, V., Thandavarayan, R. A., Giridharan, V. V., Pitchaimani, V., Afrin, M. R., Harima, M., Nakamura, T., Nakamura, M., Suzuki, K., & Watanabe, K. (2015). Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis. International Immunopharmacology, 29(2), 957-963. https://doi.org/10.1016/j.intimp.2015.10.009

Sreedhar, R, Arumugam, S, Karuppagounder, V, Thandavarayan, RA, Giridharan, VV, Pitchaimani, V, Afrin, MR, Harima, M, Nakamura, T, Nakamura, M, Suzuki, K & Watanabe, K 2015, 'Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis', International Immunopharmacology, vol. 29, no. 2, pp. 957-963. https://doi.org/10.1016/j.intimp.2015.10.009

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abstract = "Jumihaidokuto, a Japanese kampo medicine, is prescribed in Japan for its anti-inflammatory activity. Here we have examined its beneficial effects against acute colitis induced by dextran sulfate sodium (DSS) in mice. We have used C57BL/6 female mice, divided into two groups and received 3% DSS in drinking water during the experimental period (8 days). Treatment group mice received 1 g/kg/day dose of Jumihaidokuto orally whereas DSS control group received equal volume of distilled water. Normal control group mice received plain drinking water. Jumihaidokuto treatment attenuated the colitis symptoms along with suppression of various inflammatory marker proteins such as IL-1β, IL-2Rα, IL-4, CTGF and RAGE. It has also down-regulated the oxidative stress and apoptotic signaling in the colons of mice with colitis. The present study has confirmed the beneficial effects of Jumihaidokuto on DSS induced acute colitis in mice and suggests that it can be a potential agent for the treatment of colitis.",

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AU - Thandavarayan, Rajarajan A.

AU - Giridharan, Vijayasree V.

AU - Pitchaimani, Vigneshwaran

AU - Afrin, Mst Rejina

AU - Harima, Meilei

AU - Nakamura, Takashi

AU - Nakamura, Masahiko

AU - Suzuki, Kenji

AU - Watanabe, Kenichi

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N2 - Jumihaidokuto, a Japanese kampo medicine, is prescribed in Japan for its anti-inflammatory activity. Here we have examined its beneficial effects against acute colitis induced by dextran sulfate sodium (DSS) in mice. We have used C57BL/6 female mice, divided into two groups and received 3% DSS in drinking water during the experimental period (8 days). Treatment group mice received 1 g/kg/day dose of Jumihaidokuto orally whereas DSS control group received equal volume of distilled water. Normal control group mice received plain drinking water. Jumihaidokuto treatment attenuated the colitis symptoms along with suppression of various inflammatory marker proteins such as IL-1β, IL-2Rα, IL-4, CTGF and RAGE. It has also down-regulated the oxidative stress and apoptotic signaling in the colons of mice with colitis. The present study has confirmed the beneficial effects of Jumihaidokuto on DSS induced acute colitis in mice and suggests that it can be a potential agent for the treatment of colitis.

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Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis

Abstract

Keywords

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