Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis

Remya Sreedhar, Somasundaram Arumugam, Vengadeshprabhu Karuppagounder, Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Vigneshwaran Pitchaimani, Mst Rejina Afrin, Meilei Harima, Takashi Nakamura, Masahiko Nakamura, Kenji Suzuki, Kenichi Watanabe

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Jumihaidokuto, a Japanese kampo medicine, is prescribed in Japan for its anti-inflammatory activity. Here we have examined its beneficial effects against acute colitis induced by dextran sulfate sodium (DSS) in mice. We have used C57BL/6 female mice, divided into two groups and received 3% DSS in drinking water during the experimental period (8 days). Treatment group mice received 1 g/kg/day dose of Jumihaidokuto orally whereas DSS control group received equal volume of distilled water. Normal control group mice received plain drinking water. Jumihaidokuto treatment attenuated the colitis symptoms along with suppression of various inflammatory marker proteins such as IL-1β, IL-2Rα, IL-4, CTGF and RAGE. It has also down-regulated the oxidative stress and apoptotic signaling in the colons of mice with colitis. The present study has confirmed the beneficial effects of Jumihaidokuto on DSS induced acute colitis in mice and suggests that it can be a potential agent for the treatment of colitis.

Original languageEnglish (US)
Pages (from-to)957-963
Number of pages7
JournalInternational Immunopharmacology
Volume29
Issue number2
DOIs
StatePublished - Dec 1 2015

Keywords

  • Colitis
  • Inflammation
  • Inflammatory bowel diseases
  • Jumihaidokuto
  • Oxidative stress

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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