Isolation of a putative laminin binding protein from Streptococcus anginosus

Bradley L. Allen, Magnus Höök

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations

    Abstract

    Viridans streptococci, including Streptococcus anginosus, are a common cause of infective endocarditis in humans. Adherence mechanisms involved in colonization of non-diseased native valves (present in 40% of native valve endocarditis) are unknown. We have previously shown that an endocarditis isolate of S. anginosus adheres to exposed basement membrane of human and porcine valve tissue in a laminin dependent manner. We now describe the partial purification of an 80 kDa putative laminin binding protein (PLBP) by biochemical methods. Amino acid sequence of PLBP peptides is similar to substrate binding proteins of ABC transporters in other Gram-positive cocci.

    Original languageEnglish (US)
    Pages (from-to)23-31
    Number of pages9
    JournalMicrobial Pathogenesis
    Volume33
    Issue number1
    DOIs
    StatePublished - 2002

    Keywords

    • Bacterial adherence
    • Basement membrane
    • Endocarditis
    • Extracellular matrix
    • Laminin
    • Streptococcus

    ASJC Scopus subject areas

    • Microbiology
    • Infectious Diseases

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