Isolation of a putative laminin binding protein from Streptococcus anginosus

Bradley L. Allen, Magnus Höök

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Viridans streptococci, including Streptococcus anginosus, are a common cause of infective endocarditis in humans. Adherence mechanisms involved in colonization of non-diseased native valves (present in 40% of native valve endocarditis) are unknown. We have previously shown that an endocarditis isolate of S. anginosus adheres to exposed basement membrane of human and porcine valve tissue in a laminin dependent manner. We now describe the partial purification of an 80 kDa putative laminin binding protein (PLBP) by biochemical methods. Amino acid sequence of PLBP peptides is similar to substrate binding proteins of ABC transporters in other Gram-positive cocci.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalMicrobial Pathogenesis
Issue number1
StatePublished - 2002


  • Bacterial adherence
  • Basement membrane
  • Endocarditis
  • Extracellular matrix
  • Laminin
  • Streptococcus

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases


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