Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II Genes

Y. Qiu, V. Krishnan, Z. Zeng, D. J. Gilbert, Neal G. Copeland, L. Gibson, T. Yang-Feng, Nancy A. Jenkins, M. J. Tsai, S. Y. Tsai

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are orphan members of the steroid/thyroid hormone receptor superfamily. COUP-TF homologues have been cloned in many species, from Drosophila to human. The protein sequences of COUP-TFs are highly homologous across species, suggesting functional conservation. Two COUP-TF genes have been cloned from human, and their genomic organizations have been characterized. To determine whether the genomic organization is conserved between human and mouse, we isolated two mouse COUP-TF genes (I and II) and characterized their genomic structures. Both genes have relatively simple structures that are similar to those of their human counterparts. In addition, we mapped mouse COUP-TF I to the distal region of chromosome 13 and COUP. TF II to the central region of chromosome 7. Furthermore, we mapped human COUP-TF I to 5q14 of chromosome 5 and COUP-TF II to 15q26 of chromosome 15. The results demonstrate that COUP- TF genes are located in chromosomal regions that are syntenic between mouse and human.

Original languageEnglish (US)
Pages (from-to)240-246
Number of pages7
Issue number1
StatePublished - Sep 1 1995

ASJC Scopus subject areas

  • Genetics


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