Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene Era

Robert A. Britton, Su Min Chen, Deeann Wallis, Thearith Koeuth, Bradford S. Powell, Lisa G. Shaffer, David Largaespada, Nancy A. Jenkins, Neal G. Copeland, Donald L. Court, James R. Lupski

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Era is an essential GTPase that is required for proper cell cycle progression and cell division in Escherichia coli and is found in nearly all bacteria sequenced to date. To determine whether Era is also present in eukaryotic organisms, we searched the dbEST database and found EST clones coding for proteins that were similar to Era. Full sequencing of these ESTs from human and mouse identified a conserved homologue, ERAL1 (Era-like 1). ERAL1 maps to 17q11.2 in human and is located in the syntenic region of mouse chromosome 11. ERAL1 may be an attractive candidate for a tumor suppressor gene since ERAL1 is located in a chromosomal region where loss of heterozygosity is often associated with various types of cancer. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalGenomics
Volume67
Issue number1
DOIs
StatePublished - Jul 1 2000

ASJC Scopus subject areas

  • Genetics

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