Isolation and analysis of renal bismuth inclusions

Robert E. Burr, A. M. Gotto, David L. Beaver

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Typical bismuth inclusions were produced in rabbit kidney tubular cells. Histochemical examination of tissue fixed in 10% buffered neutral formalin and of fresh frozen tissue suggests that the inclusion consists of a lipid-carbohydrate-protein complex. In addition, the inclusions were obtained in a relatively pure state by ultracentrifugation and ultrasonic disintegration of kidney homogenate. Microchemical analysis of the pure inclusion fraction failed to reveal the presence of bismuth and furthers the argument that the body is a lipid-carbohydrate-protein structure.

Original languageEnglish (US)
Pages (from-to)588-591
Number of pages4
JournalToxicology and Applied Pharmacology
Issue number4
StatePublished - Jul 1965

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


Dive into the research topics of 'Isolation and analysis of renal bismuth inclusions'. Together they form a unique fingerprint.

Cite this